Matches in SemOpenAlex for { <https://semopenalex.org/work/W1016647228> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W1016647228 abstract "The cyclodecatrien collinolactone is a new microbial natural product from Streptomyces sp. Gö 40/10 and represents a hitherto unknown chemical class of substances. The structure elucidation was performed with modern spectroscopic methods (1D/2D-NMR, HR-ESI-MS, IR, UV) and revealed the unique combination of a 7-10-6-cyclodecatrien structure with a hydroxyl group, an ethyl side chain, and two lactones. Collinolactone exists as a mixture of two rotamers of a double bond in the ratio of 4:1. By feeding [13C]-labelled precursors to the producing strain, fermentation under 18O2 rich atmosphere and NMR-spectroscopic analysis of the natural product the polyketide biosynthetic origin of all carbon and oxygen atoms in the collinolactone skeleton was proven. These studies suggests a biosynthetic pathway starting from the formation of a nonaketide via PKS and macrolactonization, followed by a so far unkown rearrangement of the double bonds under formation of the tricyclic skeleton, and finally introduction of one oxygen via a Baeyer-Villiger oxygenase, forming the seven-memebered lactone. Successful derivatizations resulted in seven more compounds of this new chemical class. Four ester derivatives showed an unusual action to the microtubules (mono-astral spindles), cytotoxic and cytostatic activity.The hitherto unknown biosynthesis of 1-O-benzoyl α-L-rhamnopyranoside from Streptomyces griseoviridis (Stamm Tü 3634) were analyzed successfully by methods of natural product chemistry. Feeding experiments with [1,7-13C2]shikimic acid it was clearly showed for the first time that the starter unit benzoic acid originates directly from shikimate, and therewith, the plant-like pathway via prephenate and phenylalanine could be excluded.In a research project 15 strains of extremophilic microorganisms were analyzed in a chemical screening. Three selected strains were fermented in large scales (10 50 L). Isolation and structure elucidation of the compounds led to one new and various known substances." @default.
- W1016647228 created "2016-06-24" @default.
- W1016647228 creator A5031232308 @default.
- W1016647228 date "2022-02-20" @default.
- W1016647228 modified "2023-10-18" @default.
- W1016647228 title "Struktur und Biosynthese von Collinolacton aus Streptomyces sp. und Beiträge zum Screening neuer Wirkstoffe" @default.
- W1016647228 cites W1566286061 @default.
- W1016647228 cites W1979313157 @default.
- W1016647228 cites W2124276599 @default.
- W1016647228 cites W219270654 @default.
- W1016647228 cites W617460370 @default.
- W1016647228 doi "https://doi.org/10.53846/goediss-2054" @default.
- W1016647228 hasPublicationYear "2022" @default.
- W1016647228 type Work @default.
- W1016647228 sameAs 1016647228 @default.
- W1016647228 citedByCount "0" @default.
- W1016647228 crossrefType "dissertation" @default.
- W1016647228 hasAuthorship W1016647228A5031232308 @default.
- W1016647228 hasBestOaLocation W10166472281 @default.
- W1016647228 hasConcept C178790620 @default.
- W1016647228 hasConcept C181199279 @default.
- W1016647228 hasConcept C185592680 @default.
- W1016647228 hasConcept C2778635478 @default.
- W1016647228 hasConcept C2779396153 @default.
- W1016647228 hasConcept C2779920670 @default.
- W1016647228 hasConcept C2781440633 @default.
- W1016647228 hasConcept C523546767 @default.
- W1016647228 hasConcept C54355233 @default.
- W1016647228 hasConcept C553450214 @default.
- W1016647228 hasConcept C71240020 @default.
- W1016647228 hasConcept C86803240 @default.
- W1016647228 hasConceptScore W1016647228C178790620 @default.
- W1016647228 hasConceptScore W1016647228C181199279 @default.
- W1016647228 hasConceptScore W1016647228C185592680 @default.
- W1016647228 hasConceptScore W1016647228C2778635478 @default.
- W1016647228 hasConceptScore W1016647228C2779396153 @default.
- W1016647228 hasConceptScore W1016647228C2779920670 @default.
- W1016647228 hasConceptScore W1016647228C2781440633 @default.
- W1016647228 hasConceptScore W1016647228C523546767 @default.
- W1016647228 hasConceptScore W1016647228C54355233 @default.
- W1016647228 hasConceptScore W1016647228C553450214 @default.
- W1016647228 hasConceptScore W1016647228C71240020 @default.
- W1016647228 hasConceptScore W1016647228C86803240 @default.
- W1016647228 hasLocation W10166472281 @default.
- W1016647228 hasOpenAccess W1016647228 @default.
- W1016647228 hasPrimaryLocation W10166472281 @default.
- W1016647228 hasRelatedWork W1016647228 @default.
- W1016647228 hasRelatedWork W1995940272 @default.
- W1016647228 hasRelatedWork W2025677032 @default.
- W1016647228 hasRelatedWork W2067820849 @default.
- W1016647228 hasRelatedWork W2081347927 @default.
- W1016647228 hasRelatedWork W2111585659 @default.
- W1016647228 hasRelatedWork W2148964398 @default.
- W1016647228 hasRelatedWork W2554097823 @default.
- W1016647228 hasRelatedWork W2968255077 @default.
- W1016647228 hasRelatedWork W851530242 @default.
- W1016647228 isParatext "false" @default.
- W1016647228 isRetracted "false" @default.
- W1016647228 magId "1016647228" @default.
- W1016647228 workType "dissertation" @default.