Matches in SemOpenAlex for { <https://semopenalex.org/work/W1016985320> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W1016985320 abstract "Alzheimer's disease (AD) results from a series of dysfunctions which spread throughout thecortex in a precise spatiotemporal manner, and which subsequently give rise to acharacteristic pattern of cognitive and non-cognitive symptoms. Whilst some of thesesymptoms can be controlled with specific drug regimes, there are still no treatmentsavailable to prevent the disease. Similarly, there are no drugs available which will reverseor even halt the progression of the pathological changes which occur in the AD brain.It is hypothesised that β-amyloid deposited within the brain as plaques' causes slowlyevolving physical damage to neurons, which then triggers a stereotypical neuronal responseto trauma. This involves specific cytoskeletal alterations which give rise to thecharacteristic neuropathology of AD, and which can be experimentally modeled in both invivo and in vitro models of neuronal injury. That the pathogenesis of AD crucially involvesthe cytoskeleton, and that targeting these changes may be an effective method of delayingor even preventing neurodegeneration in AD, was explored in this thesis. A number of broad hypotheses were posed. Firstly, that there are significant cytoskeletalalterations in the AD brain which may be ameliorated by the use of cytoskeletal stabilisingagents, and which may subsequently limit the evolution of the neuropathological changescharacteristic of AD. Secondly, that metallothioneins may play a role in AD, and perhapsbe able to prevent the aberrant neuronal sprouting associated with AD.These hypotheses were addressed in a number of aims. The major conclusions from these investigations were that morphologically distinct plaque types differentially affect thearchitecture of the brain in the early and late stages of AD, to result in significantcytoskeletal alterations. Similar observations were made following experimental corticalinjury, where it was demonstrated that the administration of cytoskeletal stabilising drugscan both prevent and delay the onset of neuropathological changes. Finally,metallothioneins were shown to be upregulated in both the early stages of AD andfollowing cortical injury, suggesting that they may have a role in the pathogenesis of AD.This thesis has, therefore, demonstrated that it is possible to intervene in the sequence ofevents which ultimately leads to neurodegeneration in AD. Agents which targetcytoskeletal alterations may represent alternatives to current therapeutic strategies." @default.
- W1016985320 created "2016-06-24" @default.
- W1016985320 creator A5023428581 @default.
- W1016985320 date "2000-01-01" @default.
- W1016985320 modified "2023-09-27" @default.
- W1016985320 title "Therapeutic intervention in Alzheimer's disease" @default.
- W1016985320 hasPublicationYear "2000" @default.
- W1016985320 type Work @default.
- W1016985320 sameAs 1016985320 @default.
- W1016985320 citedByCount "0" @default.
- W1016985320 crossrefType "dissertation" @default.
- W1016985320 hasAuthorship W1016985320A5023428581 @default.
- W1016985320 hasConcept C142669718 @default.
- W1016985320 hasConcept C142724271 @default.
- W1016985320 hasConcept C1491633281 @default.
- W1016985320 hasConcept C15744967 @default.
- W1016985320 hasConcept C169760540 @default.
- W1016985320 hasConcept C2776925932 @default.
- W1016985320 hasConcept C2779134260 @default.
- W1016985320 hasConcept C2780130745 @default.
- W1016985320 hasConcept C502032728 @default.
- W1016985320 hasConcept C54355233 @default.
- W1016985320 hasConcept C71924100 @default.
- W1016985320 hasConcept C86803240 @default.
- W1016985320 hasConceptScore W1016985320C142669718 @default.
- W1016985320 hasConceptScore W1016985320C142724271 @default.
- W1016985320 hasConceptScore W1016985320C1491633281 @default.
- W1016985320 hasConceptScore W1016985320C15744967 @default.
- W1016985320 hasConceptScore W1016985320C169760540 @default.
- W1016985320 hasConceptScore W1016985320C2776925932 @default.
- W1016985320 hasConceptScore W1016985320C2779134260 @default.
- W1016985320 hasConceptScore W1016985320C2780130745 @default.
- W1016985320 hasConceptScore W1016985320C502032728 @default.
- W1016985320 hasConceptScore W1016985320C54355233 @default.
- W1016985320 hasConceptScore W1016985320C71924100 @default.
- W1016985320 hasConceptScore W1016985320C86803240 @default.
- W1016985320 hasLocation W10169853201 @default.
- W1016985320 hasOpenAccess W1016985320 @default.
- W1016985320 hasPrimaryLocation W10169853201 @default.
- W1016985320 hasRelatedWork W169833192 @default.
- W1016985320 hasRelatedWork W1839562273 @default.
- W1016985320 hasRelatedWork W1964474096 @default.
- W1016985320 hasRelatedWork W2008087702 @default.
- W1016985320 hasRelatedWork W2033795007 @default.
- W1016985320 hasRelatedWork W2068938464 @default.
- W1016985320 hasRelatedWork W2086355707 @default.
- W1016985320 hasRelatedWork W2149858231 @default.
- W1016985320 hasRelatedWork W2286917107 @default.
- W1016985320 hasRelatedWork W2316489563 @default.
- W1016985320 hasRelatedWork W2409702049 @default.
- W1016985320 hasRelatedWork W2885762453 @default.
- W1016985320 hasRelatedWork W3013399773 @default.
- W1016985320 hasRelatedWork W3040712149 @default.
- W1016985320 hasRelatedWork W3087671512 @default.
- W1016985320 hasRelatedWork W3107533468 @default.
- W1016985320 hasRelatedWork W3142100934 @default.
- W1016985320 hasRelatedWork W3171696374 @default.
- W1016985320 hasRelatedWork W56975810 @default.
- W1016985320 hasRelatedWork W88150968 @default.
- W1016985320 isParatext "false" @default.
- W1016985320 isRetracted "false" @default.
- W1016985320 magId "1016985320" @default.
- W1016985320 workType "dissertation" @default.