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- W1017176688 abstract "This chapter presents various methods of studying the effects of antibiotics and other chemotherapeutic agents and of heat, ionizing, and ultraviolet radiations on bacteria at the cellular, biochemical, and molecular levels. Bacteria which have been sublethally injured may require a “convalescent” period during which the damage to the cell is repaired. In ultraviolet-irradiated bacteria, in which cellular injury is presumably the result of the formation of pyrimidine dimers in DNA may be able to remove these dimers and hence repair the damage inflicted upon them. In the same way, heat-treated cells can repair permeability damage and damage to ribosomal RNA. Generally, a suitable procedure is to transfer treated bacteria to an appropriate liquid recovery medium wherein growth, DNA, RNA, protein, and cell wall syntheses, DNA degradation, RNA degradation, metabolic pool composition, and permeability controls can be assessed. Binding studies indicate the site of action of the drug but they do not necessarily provide direct evidence for a proposed mode of action. Quantitative and qualitative techniques are available for the determination of binding and the quantitative methods are concerned with three main problems—namely, the addition of the drug to the potential binding materials, the separation of the bound drug from that not bound, and the assay of the free and/or bound drug." @default.
- W1017176688 created "2016-06-24" @default.
- W1017176688 creator A5051806830 @default.
- W1017176688 creator A5059582357 @default.
- W1017176688 creator A5071943528 @default.
- W1017176688 date "1973-01-01" @default.
- W1017176688 modified "2023-10-16" @default.
- W1017176688 title "Chapter V Methods for Assessing Damage to Bacteria Induced by Chemical and Physical Agents" @default.
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