Matches in SemOpenAlex for { <https://semopenalex.org/work/W1017185525> ?p ?o ?g. }
- W1017185525 abstract "Publisher Summary One recent classification system views radioimaging agents as either substrate nonspecific in which the compound does not participate in a specific chemical reaction or substrate specific in which the substrate must participate in a definite chemical reaction or take part in a specific ligand-substrate interaction. Radioactive gases for lung ventilation, labeled cells as blood pool or spleen imaging agents, tagged particles for delineating capillary beds, and radiocolloids for uptake in the reticuloendothelial system are examples of substrate non-specific radiodiagnostics, Enzyme substrates or inhibitors, receptor binding ligands, metabolically trapped biomolecules and their models, and antibodies to site-associated antigens are prime examples of substrate specific radiopharmaceuticals. At present, there are 48 radiopharmaceuticals available. Technetium labeled (Tc-99m) ligands, colloids, and particles are predominate on the NDA list, but many of these substances would be classified as substrate nonspecific agents. A few organic radiopharmaceuticals, both substrate nonspecific and substrate specific, have achieved commercialization; these include radioiodinated rose bengal, fibrinogen, oleic acid, human serum albumin, hippuric acid, as well as radiomercury chlormerodrin and Se-75 selenomethionine. Contemporary research concerns of radiopharmaceutical chemists are the development of convenient and rapid labeling methods for introducing radiohalogens into biologically important carrier molecules, preparation and evaluation of radio halogenated imaging agents, synthesis and structural studies on metal ion radionuclide-containing pharmaceuticals, rapid incorporation of positron-emitting isotopes into imaging agents, antibody transport of imaging nuclides to target tissues, and quantitative structure-distribution studies of radioactive diagnostics." @default.
- W1017185525 created "2016-06-24" @default.
- W1017185525 creator A5010453110 @default.
- W1017185525 creator A5076138257 @default.
- W1017185525 date "1983-01-01" @default.
- W1017185525 modified "2023-09-27" @default.
- W1017185525 title "Chapter 30. Progress in the Development of Radioimaging Agents" @default.
- W1017185525 cites W141078459 @default.
- W1017185525 cites W1492715434 @default.
- W1017185525 cites W1494042496 @default.
- W1017185525 cites W1531729261 @default.
- W1017185525 cites W1556824047 @default.
- W1017185525 cites W1570383003 @default.
- W1017185525 cites W1762267588 @default.
- W1017185525 cites W1792755383 @default.
- W1017185525 cites W1817121396 @default.
- W1017185525 cites W1866990482 @default.
- W1017185525 cites W1874682742 @default.
- W1017185525 cites W1908100191 @default.
- W1017185525 cites W1958820650 @default.
- W1017185525 cites W1964835267 @default.
- W1017185525 cites W1967019513 @default.
- W1017185525 cites W1968142711 @default.
- W1017185525 cites W1970694966 @default.
- W1017185525 cites W1972760159 @default.
- W1017185525 cites W1972812587 @default.
- W1017185525 cites W1977829511 @default.
- W1017185525 cites W1979886614 @default.
- W1017185525 cites W1985074142 @default.
- W1017185525 cites W1986920719 @default.
- W1017185525 cites W1987111522 @default.
- W1017185525 cites W1989282320 @default.
- W1017185525 cites W1993482253 @default.
- W1017185525 cites W1997152877 @default.
- W1017185525 cites W1999321129 @default.
- W1017185525 cites W2004081276 @default.
- W1017185525 cites W2011270737 @default.
- W1017185525 cites W2014605953 @default.
- W1017185525 cites W2024425787 @default.
- W1017185525 cites W2036986376 @default.
- W1017185525 cites W2038642857 @default.
- W1017185525 cites W2040254406 @default.
- W1017185525 cites W2042116892 @default.
- W1017185525 cites W2042908248 @default.
- W1017185525 cites W2043565842 @default.
- W1017185525 cites W2049381335 @default.
- W1017185525 cites W2052126369 @default.
- W1017185525 cites W2055601231 @default.
- W1017185525 cites W2056641009 @default.
- W1017185525 cites W2057430358 @default.
- W1017185525 cites W2058149870 @default.
- W1017185525 cites W2060401436 @default.
- W1017185525 cites W2061899027 @default.
- W1017185525 cites W2063139320 @default.
- W1017185525 cites W2063429846 @default.
- W1017185525 cites W2064673675 @default.
- W1017185525 cites W2065338734 @default.
- W1017185525 cites W2066206717 @default.
- W1017185525 cites W2066381483 @default.
- W1017185525 cites W2069127212 @default.
- W1017185525 cites W2069817825 @default.
- W1017185525 cites W2071390010 @default.
- W1017185525 cites W2072207972 @default.
- W1017185525 cites W2074726993 @default.
- W1017185525 cites W2076057449 @default.
- W1017185525 cites W2077124000 @default.
- W1017185525 cites W2077990264 @default.
- W1017185525 cites W2078970852 @default.
- W1017185525 cites W2079209291 @default.
- W1017185525 cites W2081954412 @default.
- W1017185525 cites W2083110530 @default.
- W1017185525 cites W2086661996 @default.
- W1017185525 cites W2109134534 @default.
- W1017185525 cites W2118894047 @default.
- W1017185525 cites W2131011392 @default.
- W1017185525 cites W2139273052 @default.
- W1017185525 cites W2142359453 @default.
- W1017185525 cites W2153777409 @default.
- W1017185525 cites W2169515756 @default.
- W1017185525 cites W2236321085 @default.
- W1017185525 cites W2275185136 @default.
- W1017185525 cites W2283400893 @default.
- W1017185525 cites W2326148844 @default.
- W1017185525 cites W2327278530 @default.
- W1017185525 cites W2410667753 @default.
- W1017185525 cites W249933919 @default.
- W1017185525 cites W567713917 @default.
- W1017185525 cites W582337806 @default.
- W1017185525 cites W1886580109 @default.
- W1017185525 cites W1890332598 @default.
- W1017185525 doi "https://doi.org/10.1016/s0065-7743(08)60785-x" @default.
- W1017185525 hasPublicationYear "1983" @default.
- W1017185525 type Work @default.
- W1017185525 sameAs 1017185525 @default.
- W1017185525 citedByCount "1" @default.
- W1017185525 crossrefType "book-chapter" @default.
- W1017185525 hasAuthorship W1017185525A5010453110 @default.
- W1017185525 hasAuthorship W1017185525A5076138257 @default.
- W1017185525 hasConcept C111368507 @default.
- W1017185525 hasConcept C127313418 @default.