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- W1017280020 abstract "目的 观察单纯疱疹病毒-胸苷激酶/胞嘧啶脱氨酶融合自杀基因(HSV-TK/CD)对裸鼠骨肉瘤生长的影响.方法 人骨肉瘤细胞系MG-63细胞于裸鼠成瘤后将其分为6组:(1)PBS对照组;(2)重组腺病毒(adenovirus,Ad)-Lac-Z/GCV+5-FC组;(3)Ad-TK/GCV组;(4)Ad-CD/5-FC组;(5)Ad-TK/GCV+Ad-CD/5-FC组;(6)Ad-TK-CD/GCV+5-FC组.各组经治疗后观察肿瘤的生长状况及组织病理学改变.结果 (2)组与(1)组比较,肿瘤体积与肿瘤坏死程度差异无统计学意义(P＞0.05);与(1)、(2)组比较,(3)～(6)组肿瘤的生长均受到明显抑制(P＜0.05),且(5)、(6)组与(3)、(4)比较差异有统计学意义(P＜0.05).结论 融合自杀基因HSV-TK/CD对裸鼠骨肉瘤生长有明显的抑制作用。" @default.
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- W1017280020 title "Effect of CD and TK fusion suicide gene on nude mouse osteosarcoma" @default.
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