Matches in SemOpenAlex for { <https://semopenalex.org/work/W101794967> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W101794967 endingPage "63" @default.
- W101794967 startingPage "57" @default.
- W101794967 abstract "Leukotrienes (LTs) are produced by several biosynthetic enzymes including cytosolic phospholipase A2 (cPLA2), 5-lipoxygenase (5-LO), and 5-lipoxygenase activating protein (FLAP) in the perinuclear area. In the present study, we showed that pretreatment with methyl-beta-cyclodextrin (MbetaCD), a cholesterol-depleting agent, dramatically reduced the synthesis of LTs in response to A23187 in mast cells. A23187-induced LT synthesis was inhibited by pretreatment with MbetaCD, and this effect was reversed when cholesterol was added. In an approach to identifying the MbetaCD-sensitive protein(s), we observed that FLAP co-localized with flotillin-1, a lipid raft marker protein, in the lipid raft-rich low-density region of sucrose gradients. In addition, electron microscopic analysis revealed that FLAP co-localized with flotillin-1. Together, these results suggest that FLAP is present in cholesterol-rich lipid raft-like domains and that its localization in these domains is critical for LT synthesis." @default.
- W101794967 created "2016-06-24" @default.
- W101794967 creator A5014712462 @default.
- W101794967 creator A5016697158 @default.
- W101794967 creator A5034953122 @default.
- W101794967 creator A5043356571 @default.
- W101794967 creator A5043761311 @default.
- W101794967 creator A5076832811 @default.
- W101794967 date "2007-02-28" @default.
- W101794967 modified "2023-10-16" @default.
- W101794967 title "Leukotriene synthesis in response to A23187 is inhibited by methyl- beta-cyclodextrin in RBL-2H3 cells." @default.
- W101794967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17464212" @default.
- W101794967 hasPublicationYear "2007" @default.
- W101794967 type Work @default.
- W101794967 sameAs 101794967 @default.
- W101794967 citedByCount "3" @default.
- W101794967 countsByYear W1017949672014 @default.
- W101794967 crossrefType "journal-article" @default.
- W101794967 hasAuthorship W101794967A5014712462 @default.
- W101794967 hasAuthorship W101794967A5016697158 @default.
- W101794967 hasAuthorship W101794967A5034953122 @default.
- W101794967 hasAuthorship W101794967A5043356571 @default.
- W101794967 hasAuthorship W101794967A5043761311 @default.
- W101794967 hasAuthorship W101794967A5076832811 @default.
- W101794967 hasConcept C12927208 @default.
- W101794967 hasConcept C153911025 @default.
- W101794967 hasConcept C15920480 @default.
- W101794967 hasConcept C178790620 @default.
- W101794967 hasConcept C181199279 @default.
- W101794967 hasConcept C185592680 @default.
- W101794967 hasConcept C203014093 @default.
- W101794967 hasConcept C2776042228 @default.
- W101794967 hasConcept C2776452501 @default.
- W101794967 hasConcept C2776551241 @default.
- W101794967 hasConcept C2778078955 @default.
- W101794967 hasConcept C2778163477 @default.
- W101794967 hasConcept C2779433975 @default.
- W101794967 hasConcept C2780857362 @default.
- W101794967 hasConcept C2910962261 @default.
- W101794967 hasConcept C521977710 @default.
- W101794967 hasConcept C55493867 @default.
- W101794967 hasConcept C79266657 @default.
- W101794967 hasConcept C86803240 @default.
- W101794967 hasConcept C90342290 @default.
- W101794967 hasConcept C9132879 @default.
- W101794967 hasConcept C95444343 @default.
- W101794967 hasConcept C98539663 @default.
- W101794967 hasConceptScore W101794967C12927208 @default.
- W101794967 hasConceptScore W101794967C153911025 @default.
- W101794967 hasConceptScore W101794967C15920480 @default.
- W101794967 hasConceptScore W101794967C178790620 @default.
- W101794967 hasConceptScore W101794967C181199279 @default.
- W101794967 hasConceptScore W101794967C185592680 @default.
- W101794967 hasConceptScore W101794967C203014093 @default.
- W101794967 hasConceptScore W101794967C2776042228 @default.
- W101794967 hasConceptScore W101794967C2776452501 @default.
- W101794967 hasConceptScore W101794967C2776551241 @default.
- W101794967 hasConceptScore W101794967C2778078955 @default.
- W101794967 hasConceptScore W101794967C2778163477 @default.
- W101794967 hasConceptScore W101794967C2779433975 @default.
- W101794967 hasConceptScore W101794967C2780857362 @default.
- W101794967 hasConceptScore W101794967C2910962261 @default.
- W101794967 hasConceptScore W101794967C521977710 @default.
- W101794967 hasConceptScore W101794967C55493867 @default.
- W101794967 hasConceptScore W101794967C79266657 @default.
- W101794967 hasConceptScore W101794967C86803240 @default.
- W101794967 hasConceptScore W101794967C90342290 @default.
- W101794967 hasConceptScore W101794967C9132879 @default.
- W101794967 hasConceptScore W101794967C95444343 @default.
- W101794967 hasConceptScore W101794967C98539663 @default.
- W101794967 hasIssue "1" @default.
- W101794967 hasLocation W1017949671 @default.
- W101794967 hasOpenAccess W101794967 @default.
- W101794967 hasPrimaryLocation W1017949671 @default.
- W101794967 hasRelatedWork W101794967 @default.
- W101794967 hasRelatedWork W1480413910 @default.
- W101794967 hasRelatedWork W1490323568 @default.
- W101794967 hasRelatedWork W1994730705 @default.
- W101794967 hasRelatedWork W1997764369 @default.
- W101794967 hasRelatedWork W2013696756 @default.
- W101794967 hasRelatedWork W2077134680 @default.
- W101794967 hasRelatedWork W2077961451 @default.
- W101794967 hasRelatedWork W2115477213 @default.
- W101794967 hasRelatedWork W2231553588 @default.
- W101794967 hasVolume "23" @default.
- W101794967 isParatext "false" @default.
- W101794967 isRetracted "false" @default.
- W101794967 magId "101794967" @default.
- W101794967 workType "article" @default.