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• W1018297130 endingPage "62" @default.
• W1018297130 startingPage "52" @default.
• W1018297130 abstract "Intramembranous ossification is a complex multi-step process which relies on extensive interactions among bone cells and surrounding tissues. The embryonic vasculature is essential in regulating endochondral ossification; however, its role during intramembranous ossification remains poorly understood, and in vivo studies are lacking. Previous research from our lab on the development of the intramembranous scleral ossicles has demonstrated an intriguing pattern of vascular development in which the areas of future osteogenesis remain avascular until after bone induction has occurred. Such avascular zones are located directly beneath each of the conjunctival papillae, epithelial structures which provide osteogenic signals to the underlying mesenchyme. Here we provide a high-resolution map of the developing vasculature from the time of ossicle induction to mineralization using a novel technique. We show that vegfa is expressed by the papillae and nearby mesenchymal tissue throughout HH 34-37, when vascular growth is taking place, and is down-regulated thereafter. Localized inhibition of Vegf results in expansion of the avascular zone surrounding the implanted papilla and mispatterning of the scleral ossicles. These results demonstrate that Vegf signaling could provide important insights into the complex relationship between bone and vasculature during intramembranous bone development." @default.
• W1018297130 created "2016-06-24" @default.
• W1018297130 creator A5039641843 @default.
• W1018297130 creator A5058598252 @default.
• W1018297130 date "2015-10-01" @default.
• W1018297130 modified "2023-09-29" @default.
• W1018297130 title "Vascular endothelial growth factor signaling affects both angiogenesis and osteogenesis during the development of scleral ossicles" @default.
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• W1018297130 doi "https://doi.org/10.1016/j.ydbio.2015.07.014" @default.
• W1018297130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26210172" @default.
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