FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W101898077> ?p ?o ?g. }

• W101898077 endingPage "612" @default.
• W101898077 startingPage "602" @default.
• W101898077 abstract "In agonist-stimulated platelets, the integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) is converted from an inactive to an active fibrinogen receptor, thereby mediating platelet aggregation. With time after agonist addition, at least two events occur: fibrinogen becomes irreversibly bound to the platelet and, when stirring is delayed, platelets lose the ability to aggregate despite the presence of maximally bound fibrinogen. Because we previously identified an actively internalized pool of alpha IIb, beta 3 in platelets, we explored the possibility that both of these events might result from the internalization of fibrinogen bound to active alpha IIb beta 3. Under conditions of irreversible fibrinogen binding, fluorescence microscopy showed that biotinylated fibrinogen is rapidly internalized by activated platelets to a surface-inaccessible, intracellular pool. Flow cytometric analysis showed that the observed loss in accessibility to extracellular probes immediately precedes a loss in ability to the platelets to aggregate. Moreover, prevention of irreversible fibrinogen binding results in a prevention of internalization and a retention of aggregation capacity. Thus, the internalization of fibrinogen from the activated platelet surface appears to contribute not only to the irreversible phase of fibrinogen binding, but also to the downregulation of platelet adhesiveness. Fibrinogen internalization is therefore likely to represent a fundamental regulatory mechanism that modulates platelet function." @default.
• W101898077 created "2016-06-24" @default.
• W101898077 creator A5008175469 @default.
• W101898077 creator A5029725861 @default.
• W101898077 creator A5041270490 @default.
• W101898077 creator A5057557799 @default.
• W101898077 creator A5086010370 @default.
• W101898077 date "1996-01-15" @default.
• W101898077 modified "2023-09-28" @default.
• W101898077 title "Internalization of bound fibrinogen modulates platelet aggregation" @default.
• W101898077 cites W121411568 @default.
• W101898077 cites W1520666812 @default.
• W101898077 cites W1524805668 @default.
• W101898077 cites W1583092524 @default.
• W101898077 cites W1594038744 @default.
• W101898077 cites W1602760888 @default.
• W101898077 cites W1679156369 @default.
• W101898077 cites W17074206 @default.
• W101898077 cites W1785730200 @default.
• W101898077 cites W1800008863 @default.
• W101898077 cites W1964737074 @default.
• W101898077 cites W1966166239 @default.
• W101898077 cites W1978904514 @default.
• W101898077 cites W1981271685 @default.
• W101898077 cites W1992157133 @default.
• W101898077 cites W1995545637 @default.
• W101898077 cites W1998321319 @default.
• W101898077 cites W2019552715 @default.
• W101898077 cites W2039949381 @default.
• W101898077 cites W2063656702 @default.
• W101898077 cites W2065155390 @default.
• W101898077 cites W2065482230 @default.
• W101898077 cites W2073127822 @default.
• W101898077 cites W2077195655 @default.
• W101898077 cites W2079312655 @default.
• W101898077 cites W2081753893 @default.
• W101898077 cites W2093612398 @default.
• W101898077 cites W2109811381 @default.
• W101898077 cites W2110015271 @default.
• W101898077 cites W2111863453 @default.
• W101898077 cites W2122551066 @default.
• W101898077 cites W2123190470 @default.
• W101898077 cites W225477242 @default.
• W101898077 cites W2275456352 @default.
• W101898077 cites W2282876003 @default.
• W101898077 cites W2294922242 @default.
• W101898077 cites W2338645163 @default.
• W101898077 cites W2344934657 @default.
• W101898077 cites W2395159392 @default.
• W101898077 cites W2396976256 @default.
• W101898077 cites W2401610472 @default.
• W101898077 cites W2406745790 @default.
• W101898077 cites W2406827856 @default.
• W101898077 cites W2407143960 @default.
• W101898077 cites W2407760336 @default.
• W101898077 cites W2408412896 @default.
• W101898077 cites W2411344557 @default.
• W101898077 cites W2412269611 @default.
• W101898077 cites W2413515352 @default.
• W101898077 cites W2416308550 @default.
• W101898077 cites W2416806243 @default.
• W101898077 cites W2419473844 @default.
• W101898077 cites W2436090258 @default.
• W101898077 cites W2443062087 @default.
• W101898077 cites W264187420 @default.
• W101898077 cites W275055882 @default.
• W101898077 cites W332452598 @default.
• W101898077 doi "https://doi.org/10.1182/blood.v87.2.602.bloodjournal872602" @default.
• W101898077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8555482" @default.
• W101898077 hasPublicationYear "1996" @default.
• W101898077 type Work @default.
• W101898077 sameAs 101898077 @default.
• W101898077 citedByCount "54" @default.
• W101898077 countsByYear W1018980772012 @default.
• W101898077 countsByYear W1018980772013 @default.
• W101898077 countsByYear W1018980772015 @default.
• W101898077 countsByYear W1018980772016 @default.
• W101898077 countsByYear W1018980772017 @default.
• W101898077 countsByYear W1018980772018 @default.
• W101898077 countsByYear W1018980772019 @default.
• W101898077 countsByYear W1018980772021 @default.
• W101898077 countsByYear W1018980772022 @default.
• W101898077 countsByYear W1018980772023 @default.
• W101898077 crossrefType "journal-article" @default.
• W101898077 hasAuthorship W101898077A5008175469 @default.
• W101898077 hasAuthorship W101898077A5029725861 @default.
• W101898077 hasAuthorship W101898077A5041270490 @default.
• W101898077 hasAuthorship W101898077A5057557799 @default.
• W101898077 hasAuthorship W101898077A5086010370 @default.
• W101898077 hasBestOaLocation W1018980771 @default.
• W101898077 hasConcept C12554922 @default.
• W101898077 hasConcept C139770010 @default.
• W101898077 hasConcept C170493617 @default.
• W101898077 hasConcept C185592680 @default.
• W101898077 hasConcept C203014093 @default.
• W101898077 hasConcept C2776057759 @default.
• W101898077 hasConcept C2779036427 @default.
• W101898077 hasConcept C2779394231 @default.

• next