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- W1019066907 abstract "目的观察p^21HBsAg/HBsAg转基因小鼠肝脏病理学改变。方法分别选取2、6、12、18、24月龄的SPF级p^21HBsAg/HBsAg转基因小鼠和p21^＋/＋野生型小鼠，剖检进行大体观察，取肝脏及肝脏肿瘤组织，进行组织学HE染色及电镜超微结构观察。结果p^21HBsAg/HBsAg转基因小鼠肝脏大体、光镜和电镜下均有明显病理改变。随着月龄的增加。肝脏色暗质硬，表面有结节和肿瘤形成；光镜下，肝细胞浊肿，炎症细胞浸润，脂肪变性，点状、灶状和碎屑状坏死，非典型增生，肝细胞癌。癌细胞分化良好，类似肝细胞，形成索状和腺泡状结构。癌细胞核深染，具核分裂像。电镜下，癌细胞核变形，核膜曲折凹陷，线粒体肿胀，数目增多，嵴减少。4例18月龄转基因小鼠发生肝细胞癌（4／10），6例24月龄的转基因小鼠发生肝细胞癌（6／10），其中2例发现远处转移。结论p^21HBsAg/HBsAg转基因小鼠肝脏出现明显病理损害，18月龄小鼠开始发展成高分化的肝细胞癌，高龄小鼠形成的肝细胞癌能够转移。" @default.
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- W1019066907 date "2006-01-01" @default.
- W1019066907 modified "2023-09-23" @default.
- W1019066907 title "p^21HBsAg/HBsAg转基因小鼠肝脏病理学研究" @default.
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