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- W1019737008 abstract "Hyperglycemia, oxidative stress and renin-angiotensin system (RAS) dysfunction have been implicated in diabetic nephropathy (DN) progression, but the underlying molecular mechanisms are far from being fully understood. In addition to the systemic RAS, the existence of a local intrarenal RAS in renal proximal tubular cells has been recognized. Angiotensinogen is the sole precursor of all angiotensins (Ang). Intrarenal reactive oxygen species (ROS) generation, Ang II level and RAS gene expression are up-regulated in diabetes, indicating that intrarenal ROS and RAS activation play an important role in DN. The nuclear factor erythroid 2-related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1) pathway is one of the major protective processes that occurs in response to intracellular oxidative stress. Nrf2 stimulates an array of antioxidant enzymes that convert excessive ROS to less reactive or less damaging forms. Recent studies have, however, revealed that Nrf2 activation might have other undesirable effects in diabetic animals and in diabetic patients with chronic kidney disease. This mini-review summarizes current knowledge of the relationship between ROS, Nrf2 and intra renal RAS activation in DN progression as well as possible novel target(s) for DN treatment." @default.
- W1019737008 created "2016-06-24" @default.
- W1019737008 creator A5055522594 @default.
- W1019737008 creator A5057938137 @default.
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- W1019737008 date "2015-01-01" @default.
- W1019737008 modified "2023-10-11" @default.
- W1019737008 title "Reactive Oxygen Species and Nuclear Factor Erythroid 2-Related Factor 2 Activation in Diabetic Nephropathy: A Hidden Target" @default.
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- W1019737008 doi "https://doi.org/10.4172/2155-6156.1000547" @default.
- W1019737008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4511631" @default.
- W1019737008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26213634" @default.
- W1019737008 hasPublicationYear "2015" @default.
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