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- W1020165511 abstract "The endocrine hormone glucagon stimulates hepatic glucose output via its action at the glucagon receptor (GCGr) in the liver. In the diabetic state, dysregulation of glucagon secretion contributes to abnormally elevated hepatic glucose output. The inhibition of glucagon-induced hepatic glucose output via antagonism of the GCGr using small-molecule ligands is a promising mechanism for improving glycemic control in the diabetic state. Clinical data evaluating the therapeutic potential of small-molecule GCGr antagonists is currently emerging. Recently disclosed clinical data demonstrates the potential efficacy and possible therapeutic limitations of small-molecule GCGr antagonists. Recent pre-clinical work on the development of GCGr antagonists is also summarized." @default.
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- W1020165511 date "2015-10-01" @default.
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- W1020165511 title "Recent progress in the development of small-molecule glucagon receptor antagonists" @default.
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- W1020165511 doi "https://doi.org/10.1016/j.bmcl.2015.07.092" @default.
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