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- W1020488076 abstract "This chapter discusses three in vitro approaches to positional specification in the retinal–tectal system. The first in vitro analysis of retinal–tectal interactions is directed at ascertaining whether positional specification of retinal axons for a particular tectal region is reflected in the adhesive preferences of individual cells. It was reported that the induced capping of lectin receptors on trypsin-dispersed embryonic cells could be specifically inhibited by components that accumulate in organ culture medium. Thus, supernatants obtained from neural-retina and cerebral-lobe organ cultures inhibit capping of concanavalin A receptors on trypsin dissociated cells of only the homologous type. The most compelling theoretical framework from which the topographic specificity of retinal axons for the tectum has been considered is that of Sperry who suggests that the orderly projection of retinal axons onto the tectum is due to at least two complementary gradients of cytochemical affinities between retinal axons and tectal surface, the two gradients being oriented perpendicular to each other. Data accumulated in three different laboratories suggest a definite correlation between selective adhesion and positional specification of retinal axons." @default.
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- W1020488076 date "1978-01-01" @default.
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- W1020488076 title "In Vitro Approaches to Positional Specification in the Retinal-Tectal System" @default.
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- W1020488076 doi "https://doi.org/10.1016/s0079-6123(08)61016-x" @default.
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