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- W1020742504 abstract "This chapter discusses studies that focus on delayed hypersensitivity. Some of the functions ascribed to delayed hypersensitivity or cell-mediated immunity include: (1) resistance to infection by certain bacteria, fungae, viruses, and intracellular parasites; (2) immunologic responses to neoplastic cells; (3) rejection of homografts; and (4) some autoimmune diseases. It has also been established that cell-mediated reactions involve both immunologically specific and nonspecific components. The reaction of antigen with a few specifically sensitized lymphocytes results in the recruitment of a large number of nonsensitive macrophages. Recognition of the central role played by lymphocytes and macrophages in this reaction has stimulated intensive study into its mechanism. On the basis of much in vivo and in vitro experimental work, it has been proposed that the interaction of these cells may result from the production of soluble lymphocyte factors. Moreover, the production of these mediators may serve as a means of communication between sensitive lymphocytes and macrophages and perhaps other cells (polymorphonuc1ear leukocytes) involved in the cell-mediated reaction. Some of the properties of these substances and their role in cell-mediated immunity are discussed in the chapter, in addition to their clinical significance in human disease." @default.
- W1020742504 created "2016-06-24" @default.
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- W1020742504 date "1973-01-01" @default.
- W1020742504 modified "2023-09-25" @default.
- W1020742504 title "Chapter 29. Delayed Hypersensitivity: Its Mediation Through Products of Activated Lymphocytes" @default.
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- W1020742504 doi "https://doi.org/10.1016/s0065-7743(08)61257-9" @default.
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