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• W1020870984 abstract "This chapter examines the acetylcholine release from intrahippocampal septal grafts. It discusses the dependency of acetylcholine release on axonal impulse flow and behavioral activation. By using the intracerebral microdialysis technique, it is possible to measure the extracellular levels of transmitter and study the effects of different manipulations. Two sets of manipulations are performed in unrestrained normal rats, FF-lesioned rats, and rats with lesions plus either septal suspension grafts in the hippocampus or solid septal grafts in the lesion cavity. A pharmacological characterization is made by changing the axonal membrane properties by high K+ or by adding tetrodotoxin (TTX) to the perfusate. Behavioral activation is achieved either by handling the rats or by electrically stimulating the nucleus of the lateral habenula (LHb). The stimulation of the LHb, which has widespread projections to the brainstem reticular formation, causes sustained behavioral activation as well as release of noradrenaline and serotonin in the forebrain. To control for the effects of the LHb stimulation, a transection of the fasciculus retroflexus (FR), which is the outflow pathway from the LHb, is performed between two stimulations." @default.
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• W1020870984 date "1990-01-01" @default.
• W1020870984 modified "2023-10-03" @default.
• W1020870984 title "Chapter 36 Acetylcholine release from intrahippocampal septal grafts is under control by the host brain: a microdialysis study" @default.
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• W1020870984 doi "https://doi.org/10.1016/s0079-6123(08)62619-9" @default.
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