Matches in SemOpenAlex for { <https://semopenalex.org/work/W102188051> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W102188051 abstract "The objective of this study was to evaluate whether mandatory fortification of grain products with folic acid in the USA is associated with changes in histone methylation in cells involved in cervical carcinogenesis. Cervical specimens (free of pre-cancer or diagnosed with pre-cancer cervical intraepithelial neoplasia grade 3 [CIN 3]) obtained before (1990-92) or after mandatory folic acid fortification (2000-02) were used to examine the degree of histone methylation (H3 Lys-9) by immunohistochemistry. Age- and race-adjusted mean H3 Lys-9 score was significantly higher in CIN 3 specimens obtained in the post-fortification period compared to pre-fortification period (P < 0.05). In contrast, in specimens obtained from women free of CIN, H3 Lys-9 scores were significantly lower in post-fortification specimens compared to pre-fortification specimens (P < 0.05). Altered histone methylation has emerged as key to DNA methylation-related gene silencing and this type of gene silencing in cancer is accompanied by an increase in H3 Lys9 methylation. Therefore, higher Lys-9 methylation in cervical tissues of women diagnosed with CIN 3 in the post-fortification period compared to pre-fortification period suggest that fortification may have adverse effects on histone methylation in already initiated cells. Lower Lys-9 methylation in cervical cells of women free of CIN in the post fortification period compared to pre fortification on the other hand suggest that fortification is likely to protect against the initiation of carcinogenic process in the cervix. Supported by NCI R03 CA 102893" @default.
- W102188051 created "2016-06-24" @default.
- W102188051 creator A5003551118 @default.
- W102188051 creator A5033599611 @default.
- W102188051 creator A5054540023 @default.
- W102188051 creator A5055115626 @default.
- W102188051 creator A5071946805 @default.
- W102188051 creator A5076077003 @default.
- W102188051 date "2009-04-01" @default.
- W102188051 modified "2023-09-24" @default.
- W102188051 title "Mandatory fortification with folic acid in the United States appear to have adverse effects on histone methylation in women with pre‐cancer but not in women free of pre‐cancer" @default.
- W102188051 doi "https://doi.org/10.1096/fasebj.23.1_supplement.lb493" @default.
- W102188051 hasPublicationYear "2009" @default.
- W102188051 type Work @default.
- W102188051 sameAs 102188051 @default.
- W102188051 citedByCount "0" @default.
- W102188051 crossrefType "journal-article" @default.
- W102188051 hasAuthorship W102188051A5003551118 @default.
- W102188051 hasAuthorship W102188051A5033599611 @default.
- W102188051 hasAuthorship W102188051A5054540023 @default.
- W102188051 hasAuthorship W102188051A5055115626 @default.
- W102188051 hasAuthorship W102188051A5071946805 @default.
- W102188051 hasAuthorship W102188051A5076077003 @default.
- W102188051 hasConcept C104317684 @default.
- W102188051 hasConcept C119056186 @default.
- W102188051 hasConcept C121608353 @default.
- W102188051 hasConcept C126322002 @default.
- W102188051 hasConcept C131872663 @default.
- W102188051 hasConcept C150194340 @default.
- W102188051 hasConcept C190727270 @default.
- W102188051 hasConcept C198211336 @default.
- W102188051 hasConcept C2776745794 @default.
- W102188051 hasConcept C2777007973 @default.
- W102188051 hasConcept C2777343196 @default.
- W102188051 hasConcept C2778220009 @default.
- W102188051 hasConcept C31903555 @default.
- W102188051 hasConcept C33288867 @default.
- W102188051 hasConcept C41091548 @default.
- W102188051 hasConcept C42407357 @default.
- W102188051 hasConcept C54355233 @default.
- W102188051 hasConcept C71924100 @default.
- W102188051 hasConcept C86803240 @default.
- W102188051 hasConceptScore W102188051C104317684 @default.
- W102188051 hasConceptScore W102188051C119056186 @default.
- W102188051 hasConceptScore W102188051C121608353 @default.
- W102188051 hasConceptScore W102188051C126322002 @default.
- W102188051 hasConceptScore W102188051C131872663 @default.
- W102188051 hasConceptScore W102188051C150194340 @default.
- W102188051 hasConceptScore W102188051C190727270 @default.
- W102188051 hasConceptScore W102188051C198211336 @default.
- W102188051 hasConceptScore W102188051C2776745794 @default.
- W102188051 hasConceptScore W102188051C2777007973 @default.
- W102188051 hasConceptScore W102188051C2777343196 @default.
- W102188051 hasConceptScore W102188051C2778220009 @default.
- W102188051 hasConceptScore W102188051C31903555 @default.
- W102188051 hasConceptScore W102188051C33288867 @default.
- W102188051 hasConceptScore W102188051C41091548 @default.
- W102188051 hasConceptScore W102188051C42407357 @default.
- W102188051 hasConceptScore W102188051C54355233 @default.
- W102188051 hasConceptScore W102188051C71924100 @default.
- W102188051 hasConceptScore W102188051C86803240 @default.
- W102188051 hasIssue "S1" @default.
- W102188051 hasLocation W1021880511 @default.
- W102188051 hasOpenAccess W102188051 @default.
- W102188051 hasPrimaryLocation W1021880511 @default.
- W102188051 hasRelatedWork W1986736445 @default.
- W102188051 hasRelatedWork W2033874367 @default.
- W102188051 hasRelatedWork W2081243758 @default.
- W102188051 hasRelatedWork W2315444112 @default.
- W102188051 hasRelatedWork W2320537062 @default.
- W102188051 hasRelatedWork W2558279224 @default.
- W102188051 hasRelatedWork W2800416806 @default.
- W102188051 hasRelatedWork W284850018 @default.
- W102188051 hasRelatedWork W2911855642 @default.
- W102188051 hasRelatedWork W3172282045 @default.
- W102188051 hasVolume "23" @default.
- W102188051 isParatext "false" @default.
- W102188051 isRetracted "false" @default.
- W102188051 magId "102188051" @default.
- W102188051 workType "article" @default.