FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1022802383> ?p ?o ?g. }

• W1022802383 endingPage "212" @default.
• W1022802383 startingPage "205" @default.
• W1022802383 abstract "Temozolomide plays a critical role in curing glioma at present. The purpose of this work was to develop a suitable drug delivery system which could prolong the half-life, improve the brain targeting, and reduce the systemic effect of the drug. Temozolomide-liposomes were formulated by the method of proliposomes. They were found to be relatively uniform in size of 156.70 ± 11.40 nm with a narrow polydispersity index (PI) of 0.29 ± 0.04. The average drug entrapment efficiency and loading capacity were 35.45 ± 1.48% and 2.81 ± 0.20%, respectively. The pH of temozolomide-liposomes was 6.46. In vitro release studies were conducted by a dynamic dialysis. The results showed that temozolomide released slowly from liposomes compared with the solution group. The release behavior of temozolomide-liposomes was in line with First-order kinetics and Weibull equation. The pharmacokinetics study was evaluated by pharmacokinetics parameters. The t(1/2β) and MRT of temozolomide-liposomes were 3.57 times and 1.27 times greater than that of temozolomide solution. The Cmax and AUC values of temozolomide-liposomes were 1.10 times and 1.55 times greater than that of temozolomide solution. The results of pharmacokinetics study showed temozolomide-liposomes prolonged the in vivo circulation time and increased AUC. Furthermore, the biodistribution in mice showed that temozolomide-liposomes preferentially decreased the accumulation of temozolomide in heart and lung and increased the drug concentration in brain after i.v. injection, which implied that temozolomide-liposomes improved the therapeutic effect in the brain and reduced the toxicity in lung and heart." @default.
• W1022802383 created "2016-06-24" @default.
• W1022802383 creator A5026496105 @default.
• W1022802383 creator A5029422742 @default.
• W1022802383 creator A5048400895 @default.
• W1022802383 creator A5069642901 @default.
• W1022802383 creator A5085867312 @default.
• W1022802383 date "2015-01-01" @default.
• W1022802383 modified "2023-10-12" @default.
• W1022802383 title "Liposome encapsulated of temozolomide for the treatment of glioma tumor: preparation, characterization and evaluation" @default.
• W1022802383 cites W1997808257 @default.
• W1022802383 cites W2012657157 @default.
• W1022802383 cites W2012816089 @default.
• W1022802383 cites W2023949269 @default.
• W1022802383 cites W2046963620 @default.
• W1022802383 cites W2055049428 @default.
• W1022802383 cites W2056700668 @default.
• W1022802383 cites W2061863138 @default.
• W1022802383 cites W2065902356 @default.
• W1022802383 cites W2076226743 @default.
• W1022802383 cites W2086626740 @default.
• W1022802383 cites W2111834556 @default.
• W1022802383 cites W4231637567 @default.
• W1022802383 cites W4256555824 @default.
• W1022802383 doi "https://doi.org/10.5582/ddt.2015.01016" @default.
• W1022802383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26193943" @default.
• W1022802383 hasPublicationYear "2015" @default.
• W1022802383 type Work @default.
• W1022802383 sameAs 1022802383 @default.
• W1022802383 citedByCount "68" @default.
• W1022802383 countsByYear W10228023832015 @default.
• W1022802383 countsByYear W10228023832016 @default.
• W1022802383 countsByYear W10228023832017 @default.
• W1022802383 countsByYear W10228023832018 @default.
• W1022802383 countsByYear W10228023832019 @default.
• W1022802383 countsByYear W10228023832020 @default.
• W1022802383 countsByYear W10228023832021 @default.
• W1022802383 countsByYear W10228023832022 @default.
• W1022802383 countsByYear W10228023832023 @default.
• W1022802383 crossrefType "journal-article" @default.
• W1022802383 hasAuthorship W1022802383A5026496105 @default.
• W1022802383 hasAuthorship W1022802383A5029422742 @default.
• W1022802383 hasAuthorship W1022802383A5048400895 @default.
• W1022802383 hasAuthorship W1022802383A5069642901 @default.
• W1022802383 hasAuthorship W1022802383A5085867312 @default.
• W1022802383 hasBestOaLocation W10228023831 @default.
• W1022802383 hasConcept C112705442 @default.
• W1022802383 hasConcept C150903083 @default.
• W1022802383 hasConcept C178790620 @default.
• W1022802383 hasConcept C185154212 @default.
• W1022802383 hasConcept C185592680 @default.
• W1022802383 hasConcept C207001950 @default.
• W1022802383 hasConcept C22979827 @default.
• W1022802383 hasConcept C2777389519 @default.
• W1022802383 hasConcept C2777658100 @default.
• W1022802383 hasConcept C2778227246 @default.
• W1022802383 hasConcept C2779820397 @default.
• W1022802383 hasConcept C2780035454 @default.
• W1022802383 hasConcept C2780964509 @default.
• W1022802383 hasConcept C502942594 @default.
• W1022802383 hasConcept C55493867 @default.
• W1022802383 hasConcept C71924100 @default.
• W1022802383 hasConcept C86803240 @default.
• W1022802383 hasConcept C98274493 @default.
• W1022802383 hasConceptScore W1022802383C112705442 @default.
• W1022802383 hasConceptScore W1022802383C150903083 @default.
• W1022802383 hasConceptScore W1022802383C178790620 @default.
• W1022802383 hasConceptScore W1022802383C185154212 @default.
• W1022802383 hasConceptScore W1022802383C185592680 @default.
• W1022802383 hasConceptScore W1022802383C207001950 @default.
• W1022802383 hasConceptScore W1022802383C22979827 @default.
• W1022802383 hasConceptScore W1022802383C2777389519 @default.
• W1022802383 hasConceptScore W1022802383C2777658100 @default.
• W1022802383 hasConceptScore W1022802383C2778227246 @default.
• W1022802383 hasConceptScore W1022802383C2779820397 @default.
• W1022802383 hasConceptScore W1022802383C2780035454 @default.
• W1022802383 hasConceptScore W1022802383C2780964509 @default.
• W1022802383 hasConceptScore W1022802383C502942594 @default.
• W1022802383 hasConceptScore W1022802383C55493867 @default.
• W1022802383 hasConceptScore W1022802383C71924100 @default.
• W1022802383 hasConceptScore W1022802383C86803240 @default.
• W1022802383 hasConceptScore W1022802383C98274493 @default.
• W1022802383 hasIssue "3" @default.
• W1022802383 hasLocation W10228023831 @default.
• W1022802383 hasLocation W10228023832 @default.
• W1022802383 hasOpenAccess W1022802383 @default.
• W1022802383 hasPrimaryLocation W10228023831 @default.
• W1022802383 hasRelatedWork W1022802383 @default.
• W1022802383 hasRelatedWork W1906640546 @default.
• W1022802383 hasRelatedWork W2048590360 @default.
• W1022802383 hasRelatedWork W2057097799 @default.
• W1022802383 hasRelatedWork W2399459450 @default.
• W1022802383 hasRelatedWork W2400461952 @default.
• W1022802383 hasRelatedWork W2793629808 @default.
• W1022802383 hasRelatedWork W2904164222 @default.
• W1022802383 hasRelatedWork W2907895483 @default.
• W1022802383 hasRelatedWork W3000071749 @default.
• W1022802383 hasVolume "9" @default.

• next