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• W1022928148 abstract "The unicellular budding yeast,Saccharomyces cerevisiae, employs a typical eukaryotic pathway of secretion for the biogenesis of the Golgi apparatus (GA), vacuole and plasma membrane. This yeast has proven to be a powerful model organism for the identification and characterization of essential, evolutionarily conserved gene products that mediate vesicular transport in this pathway. While wildtypeS. cerevisiae cells possess a simple morphology, mutants blocked in secretion often display a dramatic accumulation of distinct membrane structures. Here we discuss the structural and functional organization of the GA in yeast, and review our current knowledge of vesicular membrane traffic to, through, and from the organelle, with an emphasis on protein sorting events. Current biochemical and genetic evidence suggests that, as in mammalian cells, the yeast GA consists of three to four distinct functional compartments:cis,medial,trans, andtrans-Golginetwork (TGN), each populated by a characteristic set of resident enzymes. Golgi-resident proteins must resist dispersion by the large flux of vesicular traffic passing through the GA; their organelle-residence is achieved through active and passive mechanisms. Protein sorting involving the budding of specialized vesicular carriers occurs at thecis-andtrans-sides of the GA: vesicles budding from thecis-Golgi mediate retrograde trafficking, e.g. retrieval of escaped ER-resident proteins and v-SNAREs back to the ER, whereas vesicles budding from thetrans-Golgi deliver cargo to the plasma membrane or the vacuole. At least two types of coat protein complexes, known as COP I and COP II, mediate protein sorting and transport between the ER and the GA, whereas the clathrin coat may be involved in Golgi-to-vacuole transport. We discuss the role of these coat complexes in transport events and in the maintenance of membranous organelles." @default.
• W1022928148 created "2016-06-24" @default.
• W1022928148 creator A5016859611 @default.
• W1022928148 creator A5020439402 @default.
• W1022928148 date "1997-01-01" @default.
• W1022928148 modified "2023-09-26" @default.
• W1022928148 title "Insights into Golgi function through mutants in yeast and animal cells" @default.
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