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- W102296235 abstract "(−)-Epigallocatechin 3- O -gallate (EGCG), a major catechin in green tea, suppresses renal failure in animals, and inhibits the growth of mouse or human mesangial cells opossum kidney proximal tubular (OK) cells and normal rat kidney interstitial fibroblast (NRK-49F) cells. In addition, EGCG induces apoptosis in OK and NRK-49F cells. However, its inhibitory effect on NRK-49F cells was weaker than that on human mesangial cells and OK cells. In addition, EGCG ameliorated the development of diabetic nephropathy and exerted a protective effect in nephropathic and nephrotoxic models, but its relationship with kidney interstitial fibroblasts is unclear. From these results, the effects of EGCG were weaker in kidney interstitial cells than mesangial cells and renal tubular cells. Therefore, EGCG is considered to improve renal fibrosis by reducing the proliferative capacity of mesangial cells." @default.
- W102296235 created "2016-06-24" @default.
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- W102296235 date "2013-01-01" @default.
- W102296235 modified "2023-10-16" @default.
- W102296235 title "(−)-Epigallocatechin 3-O-Gallate (EGCG) and Kidney Interstitial Fibroblasts" @default.
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- W102296235 doi "https://doi.org/10.1016/b978-0-12-384937-3.00091-4" @default.
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