Matches in SemOpenAlex for { <https://semopenalex.org/work/W102300507> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W102300507 abstract "The characterization of porcine antithrombin III (ATIII)-a highly powerful anticoagulant-is essential for using porcine liver in xenotransplantation applications. The objective of this study was to clarify the functions of porcine ATIII through comparison with human ATIII. We cloned porcine ATIII and compared its important functional sites with those of human ATIII. The full-length cDNA of porcine ATIII was cloned by screening a porcine liver cDNA library, and the ATIII activities of 23 pigs were determined. The full-length cDNA of porcine ATIII spanned 1498 bp and encoded 463 amino acids. Porcine ATIII shared 87.67% nucleotide identity and 89.06% amino acid identity with human ATIII. Complete identity was found at active center Arg393-Ser394, and remarkably high similarities were found at 2 critical heparin-binding sites (residues 41 through 49 and 114 through 156) and in some key residues involved in heparin binding. An ATIII assay found no significant difference between porcine and human plasma. The high level of similarity between porcine ATIII and human ATIII suggests that porcine ATIII will function in a manner similar to human ATIII in xenotransplantation." @default.
- W102300507 created "2016-06-24" @default.
- W102300507 creator A5000797717 @default.
- W102300507 creator A5042945387 @default.
- W102300507 creator A5045305757 @default.
- W102300507 creator A5048490038 @default.
- W102300507 creator A5057203303 @default.
- W102300507 creator A5069778614 @default.
- W102300507 creator A5073501391 @default.
- W102300507 creator A5075276302 @default.
- W102300507 date "2009-08-01" @default.
- W102300507 modified "2023-09-22" @default.
- W102300507 title "Cloning of the full-length cDNA of porcine antithrombin III and comparison with its human homolog." @default.
- W102300507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2779213" @default.
- W102300507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19712578" @default.
- W102300507 hasPublicationYear "2009" @default.
- W102300507 type Work @default.
- W102300507 sameAs 102300507 @default.
- W102300507 citedByCount "1" @default.
- W102300507 countsByYear W1023005072015 @default.
- W102300507 crossrefType "journal-article" @default.
- W102300507 hasAuthorship W102300507A5000797717 @default.
- W102300507 hasAuthorship W102300507A5042945387 @default.
- W102300507 hasAuthorship W102300507A5045305757 @default.
- W102300507 hasAuthorship W102300507A5048490038 @default.
- W102300507 hasAuthorship W102300507A5057203303 @default.
- W102300507 hasAuthorship W102300507A5069778614 @default.
- W102300507 hasAuthorship W102300507A5073501391 @default.
- W102300507 hasAuthorship W102300507A5075276302 @default.
- W102300507 hasConcept C104317684 @default.
- W102300507 hasConcept C121050878 @default.
- W102300507 hasConcept C126322002 @default.
- W102300507 hasConcept C153911025 @default.
- W102300507 hasConcept C187882448 @default.
- W102300507 hasConcept C189482833 @default.
- W102300507 hasConcept C199360897 @default.
- W102300507 hasConcept C2777557582 @default.
- W102300507 hasConcept C2778442404 @default.
- W102300507 hasConcept C2779026020 @default.
- W102300507 hasConcept C2911091166 @default.
- W102300507 hasConcept C41008148 @default.
- W102300507 hasConcept C55493867 @default.
- W102300507 hasConcept C71924100 @default.
- W102300507 hasConcept C86803240 @default.
- W102300507 hasConceptScore W102300507C104317684 @default.
- W102300507 hasConceptScore W102300507C121050878 @default.
- W102300507 hasConceptScore W102300507C126322002 @default.
- W102300507 hasConceptScore W102300507C153911025 @default.
- W102300507 hasConceptScore W102300507C187882448 @default.
- W102300507 hasConceptScore W102300507C189482833 @default.
- W102300507 hasConceptScore W102300507C199360897 @default.
- W102300507 hasConceptScore W102300507C2777557582 @default.
- W102300507 hasConceptScore W102300507C2778442404 @default.
- W102300507 hasConceptScore W102300507C2779026020 @default.
- W102300507 hasConceptScore W102300507C2911091166 @default.
- W102300507 hasConceptScore W102300507C41008148 @default.
- W102300507 hasConceptScore W102300507C55493867 @default.
- W102300507 hasConceptScore W102300507C71924100 @default.
- W102300507 hasConceptScore W102300507C86803240 @default.
- W102300507 hasLocation W1023005071 @default.
- W102300507 hasOpenAccess W102300507 @default.
- W102300507 hasPrimaryLocation W1023005071 @default.
- W102300507 hasRelatedWork W114706442 @default.
- W102300507 hasRelatedWork W1557726616 @default.
- W102300507 hasRelatedWork W1827667716 @default.
- W102300507 hasRelatedWork W1889917129 @default.
- W102300507 hasRelatedWork W1915414624 @default.
- W102300507 hasRelatedWork W1970705367 @default.
- W102300507 hasRelatedWork W1986858966 @default.
- W102300507 hasRelatedWork W1988472915 @default.
- W102300507 hasRelatedWork W2003781918 @default.
- W102300507 hasRelatedWork W2018155993 @default.
- W102300507 hasRelatedWork W2022995855 @default.
- W102300507 hasRelatedWork W2039793069 @default.
- W102300507 hasRelatedWork W2049626340 @default.
- W102300507 hasRelatedWork W2051582871 @default.
- W102300507 hasRelatedWork W2083968879 @default.
- W102300507 hasRelatedWork W2085033539 @default.
- W102300507 hasRelatedWork W2093796745 @default.
- W102300507 hasRelatedWork W2115715429 @default.
- W102300507 hasRelatedWork W2412735115 @default.
- W102300507 hasRelatedWork W2527823583 @default.
- W102300507 isParatext "false" @default.
- W102300507 isRetracted "false" @default.
- W102300507 magId "102300507" @default.
- W102300507 workType "article" @default.