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- W1023473612 endingPage "290" @default.
- W1023473612 startingPage "265" @default.
- W1023473612 abstract "DNA methyltransferases (DNMTs) are promising epigenetic targets for the development of novel anticancer drugs and other diseases. 5-Azacytidine and decitabine are DNMT inhibitors (DNMTi) approved by the Food and Drug Administration of the United States for the treatment of myelodysplastic syndromes. These two drugs have demonstrated significant, although usually transient, improvement in patient survival. The promising clinical success and limitations of these approved drugs have prompted the search for novel agents targeting DNMTs using a blend of complementary methods including chemical synthesis, rational search in natural sources and food components, and high-throughput screening. This chapter discusses the therapeutic significance of DNMTs in cancer and successful applications of DNMTi in the clinic. We also present advances on experimental assays to screen compound collections and the current status of DNMTi development. Additionally, we elaborate on data sources and recent applications of chemoinformatics and molecular modeling that exemplify the significance of ChemEpinformatics in translational epigenetics." @default.
- W1023473612 created "2016-06-24" @default.
- W1023473612 creator A5036035049 @default.
- W1023473612 creator A5070192692 @default.
- W1023473612 creator A5086421148 @default.
- W1023473612 date "2015-01-01" @default.
- W1023473612 modified "2023-10-04" @default.
- W1023473612 title "DNA Methyltransferase Inhibitors for Cancer Therapy" @default.
- W1023473612 cites W130587384 @default.
- W1023473612 cites W1516432813 @default.
- W1023473612 cites W1966010937 @default.
- W1023473612 cites W1969910220 @default.
- W1023473612 cites W1970825229 @default.
- W1023473612 cites W1972635017 @default.
- W1023473612 cites W1978419388 @default.
- W1023473612 cites W1979273476 @default.
- W1023473612 cites W1980264281 @default.
- W1023473612 cites W1980838126 @default.
- W1023473612 cites W1980937575 @default.
- W1023473612 cites W1981354816 @default.
- W1023473612 cites W1983910249 @default.
- W1023473612 cites W1984260723 @default.
- W1023473612 cites W1984655439 @default.
- W1023473612 cites W1988452823 @default.
- W1023473612 cites W1995070143 @default.
- W1023473612 cites W1995204800 @default.
- W1023473612 cites W1996874832 @default.
- W1023473612 cites W1997275786 @default.
- W1023473612 cites W1997453048 @default.
- W1023473612 cites W1997974036 @default.
- W1023473612 cites W1998351475 @default.
- W1023473612 cites W2006500779 @default.
- W1023473612 cites W2009752721 @default.
- W1023473612 cites W2010287588 @default.
- W1023473612 cites W2013154874 @default.
- W1023473612 cites W2013195055 @default.
- W1023473612 cites W2014408660 @default.
- W1023473612 cites W2017394727 @default.
- W1023473612 cites W2018292769 @default.
- W1023473612 cites W2018822143 @default.
- W1023473612 cites W2019812667 @default.
- W1023473612 cites W2020155551 @default.
- W1023473612 cites W2021459974 @default.
- W1023473612 cites W2029070438 @default.
- W1023473612 cites W2029197798 @default.
- W1023473612 cites W2029874395 @default.
- W1023473612 cites W2030106108 @default.
- W1023473612 cites W2031871849 @default.
- W1023473612 cites W2036276852 @default.
- W1023473612 cites W2041231836 @default.
- W1023473612 cites W2043934142 @default.
- W1023473612 cites W2046509449 @default.
- W1023473612 cites W2048389974 @default.
- W1023473612 cites W2053213384 @default.
- W1023473612 cites W2061891352 @default.
- W1023473612 cites W2062093164 @default.
- W1023473612 cites W2068469195 @default.
- W1023473612 cites W2069796345 @default.
- W1023473612 cites W2070746165 @default.
- W1023473612 cites W2076227442 @default.
- W1023473612 cites W2077890483 @default.
- W1023473612 cites W2078443326 @default.
- W1023473612 cites W2078617491 @default.
- W1023473612 cites W2081052876 @default.
- W1023473612 cites W2081152501 @default.
- W1023473612 cites W2083535257 @default.
- W1023473612 cites W2083787690 @default.
- W1023473612 cites W2083843551 @default.
- W1023473612 cites W2087360288 @default.
- W1023473612 cites W2089417246 @default.
- W1023473612 cites W2093315645 @default.
- W1023473612 cites W2100645337 @default.
- W1023473612 cites W2101668125 @default.
- W1023473612 cites W2108674003 @default.
- W1023473612 cites W2122619503 @default.
- W1023473612 cites W2124418078 @default.
- W1023473612 cites W2127540087 @default.
- W1023473612 cites W2132005991 @default.
- W1023473612 cites W2136270288 @default.
- W1023473612 cites W2139620481 @default.
- W1023473612 cites W2139686661 @default.
- W1023473612 cites W2141749176 @default.
- W1023473612 cites W2143617373 @default.
- W1023473612 cites W2144720261 @default.
- W1023473612 cites W2145337538 @default.
- W1023473612 cites W2145461895 @default.
- W1023473612 cites W2145750252 @default.
- W1023473612 cites W2147187842 @default.
- W1023473612 cites W2147415210 @default.
- W1023473612 cites W2147596629 @default.
- W1023473612 cites W2149816812 @default.
- W1023473612 cites W2149858761 @default.
- W1023473612 cites W2152757219 @default.
- W1023473612 cites W2155701198 @default.
- W1023473612 cites W2156165856 @default.
- W1023473612 cites W2157132743 @default.
- W1023473612 cites W2158526038 @default.
- W1023473612 cites W2159173286 @default.