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• W1023675455 endingPage "411" @default.
• W1023675455 startingPage "393" @default.
• W1023675455 abstract "Osteoporosis has long been recognized as a major cause of morbidity and mortality in the elderly, especially in women. Because of its prevalence and clinical importance, most of the research, therapeutic, and educational efforts have focused on postmenopausal osteoporosis. In 1940, Fuller Albright proposed that estrogen deficiency was the causative factor in postmenopausal osteoporosis, the first suggestion that gonadal steroids play an essential role in bone metabolism (1). Albright and colleagues then demonstrated that estrogen administration reverses the negative calcium balance associated with estrogen deficiency and that both estrogens and androgens induce positive calcium balance in estrogen deficient osteoporotic women and eugonadal osteoporotic men (2). Based on these early observations and accumulating experimental data, estrogen replacement soon became a powerful therapeutic agent in the treatment of postmenopausal osteoporosis." @default.
• W1023675455 created "2016-06-24" @default.
• W1023675455 creator A5013380382 @default.
• W1023675455 creator A5024994311 @default.
• W1023675455 date "2003-01-01" @default.
• W1023675455 modified "2023-09-23" @default.
• W1023675455 title "Gonadal Steroids and the Skeleton in Men" @default.
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