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- W102384057 endingPage "676" @default.
- W102384057 startingPage "665" @default.
- W102384057 abstract "The zona pellucida (ZP) is a specialized extracellular coat that surrounds the plasma membrane of mammalian eggs. Its presence is essential for successful completion of oogenesis, fertilization and preimplantation development. The ZP is composed of only a few glycoproteins which are organized into long crosslinked fibrils that constitute the extracellular coat. A hallmark of ZP glycoproteins is the presence of a ZP domain, a region of polypeptide responsible for polymerization of the glycoproteins into a network of interconnected fibrils. The mouse egg ZP consists of only three glycoproteins, called ZP1, ZP2, and ZP3, that are synthesized and secreted exclusively by growing oocytes. One of the glycoproteins, ZP3, serves as both a binding partner for sperm and inducer of sperm exocytosis, the acrosome reaction. Female mice lacking ZP3 fail to assemble a ZP around growing oocytes and are completely infertile. Sperm bind to the carboxy-terminal region of ZP3 polypeptide encoded by ZP3 exon-7 and binding is sufficient to induce sperm to complete the acrosome reaction. Whether sperm recognize and bind to ZP3 polypeptide, oligosaccharide, or both remains an unresolved issue. Purified ZP3 self-assembles into long homomeric fibrils under non-denaturing conditions. Apparently, sperm added to ZP3 bind to the fibrils and are prevented from binding to ovulated eggs in vitro. These, as well as other aspects of ZP structure and function are addressed in this article." @default.
- W102384057 created "2016-06-24" @default.
- W102384057 creator A5005791740 @default.
- W102384057 creator A5073446980 @default.
- W102384057 date "2008-01-01" @default.
- W102384057 modified "2023-10-17" @default.
- W102384057 title "Mammalian fertilization:the eggs multifunctional zona pellucida" @default.
- W102384057 cites W123625339 @default.
- W102384057 cites W127566521 @default.
- W102384057 cites W1494884984 @default.
- W102384057 cites W1500478148 @default.
- W102384057 cites W1506187368 @default.
- W102384057 cites W1509319008 @default.
- W102384057 cites W1522789903 @default.
- W102384057 cites W1552661248 @default.
- W102384057 cites W1578984238 @default.
- W102384057 cites W1589394688 @default.
- W102384057 cites W1771107213 @default.
- W102384057 cites W1774474273 @default.
- W102384057 cites W1794113482 @default.
- W102384057 cites W1918243751 @default.
- W102384057 cites W1947389262 @default.
- W102384057 cites W1947785291 @default.
- W102384057 cites W1957459929 @default.
- W102384057 cites W1963565317 @default.
- W102384057 cites W1966371500 @default.
- W102384057 cites W1968067554 @default.
- W102384057 cites W1968843575 @default.
- W102384057 cites W1969613597 @default.
- W102384057 cites W1981717431 @default.
- W102384057 cites W1984779994 @default.
- W102384057 cites W1985993109 @default.
- W102384057 cites W1988279879 @default.
- W102384057 cites W1993059461 @default.
- W102384057 cites W1998344765 @default.
- W102384057 cites W1998660355 @default.
- W102384057 cites W1998683445 @default.
- W102384057 cites W2001892434 @default.
- W102384057 cites W2002504846 @default.
- W102384057 cites W2005038934 @default.
- W102384057 cites W2005668319 @default.
- W102384057 cites W2008039120 @default.
- W102384057 cites W2008084413 @default.
- W102384057 cites W2010493175 @default.
- W102384057 cites W2011211732 @default.
- W102384057 cites W2014239430 @default.
- W102384057 cites W2014284201 @default.
- W102384057 cites W2014463976 @default.
- W102384057 cites W2014999503 @default.
- W102384057 cites W2015968331 @default.
- W102384057 cites W2018704736 @default.
- W102384057 cites W2018870032 @default.
- W102384057 cites W2022628365 @default.
- W102384057 cites W2022836138 @default.
- W102384057 cites W2025356775 @default.
- W102384057 cites W2025977281 @default.
- W102384057 cites W2029268138 @default.
- W102384057 cites W2031060802 @default.
- W102384057 cites W2036844600 @default.
- W102384057 cites W2038147488 @default.
- W102384057 cites W2039279157 @default.
- W102384057 cites W2050649920 @default.
- W102384057 cites W2052865938 @default.
- W102384057 cites W2053086724 @default.
- W102384057 cites W2053921943 @default.
- W102384057 cites W2055918259 @default.
- W102384057 cites W2060769407 @default.
- W102384057 cites W2062850242 @default.
- W102384057 cites W2063887226 @default.
- W102384057 cites W2065892941 @default.
- W102384057 cites W2067134845 @default.
- W102384057 cites W2069477911 @default.
- W102384057 cites W2070107829 @default.
- W102384057 cites W2071328400 @default.
- W102384057 cites W2071348291 @default.
- W102384057 cites W2075271057 @default.
- W102384057 cites W2076328191 @default.
- W102384057 cites W2076733366 @default.
- W102384057 cites W2076900020 @default.
- W102384057 cites W2081567987 @default.
- W102384057 cites W2082655555 @default.
- W102384057 cites W2082827470 @default.
- W102384057 cites W2083699738 @default.
- W102384057 cites W2085101416 @default.
- W102384057 cites W2085674561 @default.
- W102384057 cites W2089140462 @default.
- W102384057 cites W2089826191 @default.
- W102384057 cites W2091873591 @default.
- W102384057 cites W2092102874 @default.
- W102384057 cites W2093409717 @default.
- W102384057 cites W2093661199 @default.
- W102384057 cites W2094722022 @default.
- W102384057 cites W2095122911 @default.
- W102384057 cites W2095345762 @default.
- W102384057 cites W2097528604 @default.
- W102384057 cites W2101183221 @default.
- W102384057 cites W2107419984 @default.
- W102384057 cites W2111557605 @default.