FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1023952082> ?p ?o ?g. }

• W1023952082 endingPage "e0133566" @default.
• W1023952082 startingPage "e0133566" @default.
• W1023952082 abstract "Background and Purpose In the treatment of patients with suspected acute ischemic stroke, increasing evidence suggests the importance of measuring the volume of the irreversibly injured “ischemic core.” The gold standard method for doing this in the clinical setting is diffusion-weighted magnetic resonance imaging (DWI), but many authors suggest that maps of regional cerebral blood volume (CBV) derived from computed tomography perfusion imaging (CTP) can substitute for DWI. We sought to determine whether DWI and CTP-derived CBV maps are equivalent in measuring core volume. Methods 58 patients with suspected stroke underwent CTP and DWI within 6 hours of symptom onset. We measured low-CBV lesion volumes using three methods: “objective absolute,” i.e. the volume of tissue with CBV below each of six published absolute thresholds (0.9–2.5 mL/100 g), “objective relative,” whose six thresholds (51%-60%) were fractions of mean contralateral CBV, and “subjective,” in which two radiologists (R1, R2) outlined lesions subjectively. We assessed the sensitivity and specificity of each method, threshold, and radiologist in detecting infarction, and the degree to which each over- or underestimated the DWI core volume. Additionally, in the subset of 32 patients for whom follow-up CT or MRI was available, we measured the proportion of CBV- or DWI-defined core lesions that exceeded the follow-up infarct volume, and the maximum amount by which this occurred. Results DWI was positive in 72% (42/58) of patients. CBV maps’ sensitivity/specificity in identifying DWI-positive patients were 100%/0% for both objective methods with all thresholds, 43%/94% for R1, and 83%/44% for R2. Mean core overestimation was 156–699 mL for objective absolute thresholds, and 127–200 mL for objective relative thresholds. For R1 and R2, respectively, mean±SD subjective overestimation were -11±26 mL and -11±23 mL, but subjective volumes differed from DWI volumes by up to 117 and 124 mL in individual patients. Inter-rater agreement regarding the presence of infarction on CBV maps was poor (kappa = 0.21). Core lesions defined by the six objective absolute CBV thresholds exceeded follow-up infarct volumes for 81%-100% of patients, by up to 430–1002 mL. Core estimates produced by objective relative thresholds exceeded follow-up volumes in 91% of patients, by up to 210-280 mL. Subjective lesions defined by R1 and R2 exceeded follow-up volumes in 18% and 26% of cases, by up to 71 and 15 mL, respectively. Only 1 of 23 DWI lesions (4%) exceeded final infarct volume, by 3 mL. Conclusion CTP-derived CBV maps cannot reliably substitute for DWI in measuring core volume, or even establish which patients have DWI lesions." @default.
• W1023952082 created "2016-06-24" @default.
• W1023952082 creator A5010029432 @default.
• W1023952082 creator A5024217801 @default.
• W1023952082 creator A5026314299 @default.
• W1023952082 creator A5034596298 @default.
• W1023952082 creator A5069814883 @default.
• W1023952082 creator A5082115758 @default.
• W1023952082 creator A5088527297 @default.
• W1023952082 date "2015-07-20" @default.
• W1023952082 modified "2023-10-16" @default.
• W1023952082 title "In Acute Stroke, Can CT Perfusion-Derived Cerebral Blood Volume Maps Substitute for Diffusion-Weighted Imaging in Identifying the Ischemic Core?" @default.
• W1023952082 cites W1578829741 @default.
• W1023952082 cites W1965384106 @default.
• W1023952082 cites W1969295152 @default.
• W1023952082 cites W1972869299 @default.
• W1023952082 cites W1973913902 @default.
• W1023952082 cites W1988591730 @default.
• W1023952082 cites W1990024475 @default.
• W1023952082 cites W1990814258 @default.
• W1023952082 cites W1990870045 @default.
• W1023952082 cites W1991134549 @default.
• W1023952082 cites W1995425094 @default.
• W1023952082 cites W2001414884 @default.
• W1023952082 cites W2004309411 @default.
• W1023952082 cites W2017501282 @default.
• W1023952082 cites W2031384650 @default.
• W1023952082 cites W2041650928 @default.
• W1023952082 cites W2043151182 @default.
• W1023952082 cites W2048012763 @default.
• W1023952082 cites W2072308062 @default.
• W1023952082 cites W2080190646 @default.
• W1023952082 cites W2088139330 @default.
• W1023952082 cites W2103134658 @default.
• W1023952082 cites W2119201710 @default.
• W1023952082 cites W2121967659 @default.
• W1023952082 cites W2123617965 @default.
• W1023952082 cites W2123894485 @default.
• W1023952082 cites W2126255160 @default.
• W1023952082 cites W2134908435 @default.
• W1023952082 cites W2140327468 @default.
• W1023952082 cites W2150276788 @default.
• W1023952082 cites W2152705022 @default.
• W1023952082 cites W2156208246 @default.
• W1023952082 cites W2166152175 @default.
• W1023952082 cites W2171165037 @default.
• W1023952082 cites W2518451396 @default.
• W1023952082 cites W4246731685 @default.
• W1023952082 doi "https://doi.org/10.1371/journal.pone.0133566" @default.
• W1023952082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4508041" @default.
• W1023952082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26193486" @default.
• W1023952082 hasPublicationYear "2015" @default.
• W1023952082 type Work @default.
• W1023952082 sameAs 1023952082 @default.
• W1023952082 citedByCount "32" @default.
• W1023952082 countsByYear W10239520822016 @default.
• W1023952082 countsByYear W10239520822017 @default.
• W1023952082 countsByYear W10239520822018 @default.
• W1023952082 countsByYear W10239520822019 @default.
• W1023952082 countsByYear W10239520822020 @default.
• W1023952082 countsByYear W10239520822021 @default.
• W1023952082 countsByYear W10239520822022 @default.
• W1023952082 countsByYear W10239520822023 @default.
• W1023952082 crossrefType "journal-article" @default.
• W1023952082 hasAuthorship W1023952082A5010029432 @default.
• W1023952082 hasAuthorship W1023952082A5024217801 @default.
• W1023952082 hasAuthorship W1023952082A5026314299 @default.
• W1023952082 hasAuthorship W1023952082A5034596298 @default.
• W1023952082 hasAuthorship W1023952082A5069814883 @default.
• W1023952082 hasAuthorship W1023952082A5082115758 @default.
• W1023952082 hasAuthorship W1023952082A5088527297 @default.
• W1023952082 hasBestOaLocation W10239520821 @default.
• W1023952082 hasConcept C126322002 @default.
• W1023952082 hasConcept C126838900 @default.
• W1023952082 hasConcept C127413603 @default.
• W1023952082 hasConcept C135691158 @default.
• W1023952082 hasConcept C143409427 @default.
• W1023952082 hasConcept C146957229 @default.
• W1023952082 hasConcept C149550507 @default.
• W1023952082 hasConcept C164705383 @default.
• W1023952082 hasConcept C2776572282 @default.
• W1023952082 hasConcept C2777798775 @default.
• W1023952082 hasConcept C2780645631 @default.
• W1023952082 hasConcept C2982720008 @default.
• W1023952082 hasConcept C2989005 @default.
• W1023952082 hasConcept C3020166492 @default.
• W1023952082 hasConcept C37557685 @default.
• W1023952082 hasConcept C40993552 @default.
• W1023952082 hasConcept C500558357 @default.
• W1023952082 hasConcept C71924100 @default.
• W1023952082 hasConcept C78519656 @default.
• W1023952082 hasConceptScore W1023952082C126322002 @default.
• W1023952082 hasConceptScore W1023952082C126838900 @default.
• W1023952082 hasConceptScore W1023952082C127413603 @default.
• W1023952082 hasConceptScore W1023952082C135691158 @default.
• W1023952082 hasConceptScore W1023952082C143409427 @default.
• W1023952082 hasConceptScore W1023952082C146957229 @default.
• W1023952082 hasConceptScore W1023952082C149550507 @default.

• next