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- W102404688 abstract "Many countries are stepping into aging society. The increasing proportion of elderly in population is in high risk of having more aging-associated diseases. Alzheimer’s disease (AD) is the most common age-associated disorder, characterized by progressive dementia. Nowadays, 30 million people have suffered the disorder. However, no cure is applied in clinic except symptom-relieving strategy. Epidemiological studies have shown the reverse association between consumption of nutritional diets rich in anti-oxidants and developing neurodegenerative diseases. Therefore, healthy aging should be put forward by introducing healthy life style, in which good nutrition plays a key role. Oxyresveratrol (OXY) is a natural hydroxystilbene present in mulberry fruit (fig.1), or fruits of several trees belonging to Artocarpus genus. It has been found as tyrosinase inhibitor. Correspondence/Reprint request: Dr. Raymond C. C. Chang, Rm L1-49, Laboratory Block, Faculty of Medicine Building, Department of Anatomy, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong. E-mail: rccchang@hkucc.hku.hk Raymond Chuen-Chung Chang et al. 156 Recently, increasing lines of evidence have demonstrated its neuroprotective effects on age-associated diseases such as AD and stroke. Apart from conventional antioxidant property and the permeability to blood-brain-barrier, we focus on reviewing the anti-inflammatory activity, cell signaling regulation property, as well as its bioavailability in vivo and in vitro. Findings enlighten that nutritional supplement, such as fruits containing OXY may retard aging or benefit healthy aging, which is helpful to reduce the risk of neurodegeneration in elderly population." @default.
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- W102404688 date "2010-01-01" @default.
- W102404688 modified "2023-10-01" @default.
- W102404688 title "Neuroprotective effects of oxyresveratrol from fruit against neurodegeneration in Alzheimer's disease" @default.
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