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- W1024255874 abstract "目的探讨脑出血后血肿周围组织血红素氧合酶-1（HO-1）、胶质纤维酸性蛋白（GFAP）和细胞周期蛋白D1（cvclinD1）表达规律，及其与神经修复之间的关系。方法HE染色观察脑出血后神经元和星形胶质细胞形态变化，免疫组织化学染色检测脑出血后不同时间点血肿周固组织HO-1、GFAP和cvclinD1表达水平。结果脑出血后2h星形胶质细胞胞质内即开始表达HO-1[（5．30±1．00、）个，高倍视野]、GFAP[（22．60±1．40）个／高倍视野]和cyclinD1[（11．50±1．20）个，高倍视野]，达峰值水平后逐渐下降，脑出血后不同时间点表达水平均高于健侧正常脑组织．且差异具有统计学意义（均P=0.000）。结论人脑出血后血肿周围组织HO-1、GFAP和cvclinD1表达变化呈“抛物线”样，HO-1和evclinD1共同参与了脑出血后星形胶质细胞的增生与活化，以及脑出血后的继发性损伤和修复。" @default.
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- W1024255874 date "2011-01-01" @default.
- W1024255874 modified "2023-09-27" @default.
- W1024255874 title "人脑出血后血肿周围组织HO-1、GFAP和cyclinD1的表达研究" @default.
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