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- W1024424511 abstract "Gene targeting technology is an important means to investigate gene functions,but its efficiency of gene targeting is very low,especially for somatic cell targeting. Artificially induced double-strand breaks (DSB) and triplex forming oligonucleotide (TFO) are currently developed methods to improve the targeting efficiency. This paper summarized the basic principles,design ideas and application in gene targeting efficiency improvement of these two methods,analyzed and compared their characteristics,and finally proposed prospects for their future development." @default.
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- W1024424511 date "2013-01-01" @default.
- W1024424511 modified "2023-09-24" @default.
- W1024424511 title "Application of Artificially Induced Double-strand Breaks （DSB） and Triplex-forming Oligonucleotides （TFO） in the Improvement of Gene Targeting Efficiency" @default.
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