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- W1024521570 abstract "Our entry into “next-generation” hormonal therapy for metastatic castration-resistant prostate cancer (mCRPC) following the FDA approvals of abiraterone and enzalutamide has matured enough for some important, albeit early, observations: 20% to 30% of patients are unresponsive to both of these agents up front; 20% to 30% have transient responses of 2 to 3 months; and the remainder have significant benefit, with a small subset having long-term response.1 Additionally, we have observed a high degree of cross-resistance between abiraterone and enzalutamide, dashing our hopes for the routine sequential use of these well-tolerated drugs." @default.
- W1024521570 created "2016-06-24" @default.
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- W1024521570 date "2015-07-20" @default.
- W1024521570 modified "2023-09-28" @default.
- W1024521570 title "Sequence and Cross-Resistance: Challenges for Optimal Use of Next-Generation Anti-Androgen Therapies" @default.
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