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- W1024748644 endingPage "244" @default.
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- W1024748644 abstract "The chapter discusses the studies on genes that are transcribed by RNA polymerase II— that is, genes that, for the most part, give rise to mRNAs. It reviews what is know about the mechanisms and pathways of mRNA synthesis, concentrating on what has been learned from in vitro systems. Very little is known about the molecular mechanisms by which the expression of mammalian genes is regulated, but from the little that have been learned is also discussed in the chapter. It also deals with the genetics of mRNA synthesis, in particular, advances that have arisen from the application of in vitro mutagenesis technology will be emphasized. Studies on genes transcribed by other polymerases (e.g., nuclear RNA polymerases I and III, and various viral RNA polymerases) are discussed only to the extent that they complement or extend conclusions obtained from RNA polymerase II systems. The development of in vitro systems derived from mammalian cells that accurately reproduce many of the steps involved in RNA synthesis has begun to provide insights into the mechanisms and enzymology of gene expression and regulation." @default.
- W1024748644 created "2016-06-24" @default.
- W1024748644 creator A5075369042 @default.
- W1024748644 date "1983-01-01" @default.
- W1024748644 modified "2023-10-16" @default.
- W1024748644 title "Analysis of the Expression of Genes Encoding Animal mRNA by in Vitro Techniques" @default.
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