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• W1024839969 endingPage "334" @default.
• W1024839969 startingPage "281" @default.
• W1024839969 abstract "The mechanism or mechanisms by which viruses cause tumors represents a complex in vivo problem. The interactions of viruses such as simian virus 40 (SV40) and Rous sarcoma virus (RSV) with sensitive target cells have shown that integration into host cell DNA of specific viral genes is essential for initiation of cellular transformation. By combining findings relative to transformation in vitro with observations on experimental tumors, exciting new findings are emerging which suggest that some subacute transforming avian retroviruses may induce tumors via a mechanism not unlike that ascribed to the acutely transforming viruses, but using a cellular gene. It is reported that acute transforming viruses act as an initiator of transformation via immunological or other mechanisms. The chapter presents the examples of both experimental and naturally occurring tumors or transformed cells which have clear associations with certain viruses, but that fails to yield evidence for retention of viral genes or gene products. Such tumors raise the possibilities of transient virus-cell interactions which nevertheless are sufficient for tumorigenesis." @default.
• W1024839969 created "2016-06-24" @default.
• W1024839969 creator A5033823459 @default.
• W1024839969 creator A5061236707 @default.
• W1024839969 date "1982-01-01" @default.
• W1024839969 modified "2023-09-23" @default.
• W1024839969 title "Mechanisms of Viral Tumorigenesis" @default.
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