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- W1025016891 abstract "Morfologiai es biokemiai vizsgalataink arra utalnak, hogy a a genotoxikus hatasok kategorizalhatok az okozott kromatin valtozasok alapjan. A kemotoxikus valtozasok potencialis diagnosztikus jelentősege miatt vizsgaltuk a nehezfemek (elsősosrban kadmium) (Banfalvi et al., 2005), a gamma sugarzas (Nagy et al., 2004), az UVB sugarzas (Ujvarosi et al., 2007) es a carcinogen (dimetilnitrozamin) hatasara bekovetkező kromatin valtozasokat (Trencsenyi et al., 2007). Kadmium kezeles jellegzetes szakadasokat es nagy lyukakat hozott letre a sejtmagban. A gamma sugarzas preapoptotikus hatasara: a. a sejtek es sejtmagok merete megnőtt, b. DNA tartalmuk a sejtciklus minden szakaszaban kisebb volt a normal kezeletlen populaciohoz kepest, c. a sejtciklus a korai S fazisban leallt (2,4 C erteknel), d. a kromatin kondenzalas annak fibrillaris szakaszaban akadt el, e. az apoptotikus testek szama es nagysaga a sejtciklus haladasavalforditva aranyos: sok apro apoptotikus testtel az S fazis elejen es keves nagy apoptotikus testtel az S fazis vegen. A CHO sejtekben mert vizsgalatokat human K562 sejteken megerősitettuk. UVB sugarzas hatasara a kromoszomak nem voltak lathatok, a serules hatasara vekony osszefuggő kromatin fatyol vonta be mind az interfazisos, mind a metafazisos kromoszomakat. | Morphological and biochemical studies after genotoxic treatments suggest that the consequences of various chromatin injuries can be categorized based on the assessment of injury-specific chromatin changes. Due to its diagnostic significance, we have started to determine and systematize the effects of heavy metals, primarily cadmium treatment (Banfalvi et al., 2005), gamma irradiation (Nagy et al., 2004) and UV irradiation (Ujvarosi et al., 2007). After cadmium treatment and have seen the same large extensive disruptions and holes in the nuclear membrane and sticky incompletely folded chromosomes typical for cadmium treatment (Nagy et al., 2004; Banfalvi et al., 2007). Preapoptotic changes upon γ-irradiation manifested as: (a) The cellular and nuclear sizes increased. (b) The DNA content was lower in each elutriated subpopulation of cells. (c) The progression of the cell cycle was arrested in the early S phase at 2.4 C value. (d) The chromatin condensation was blocked at its fibrillary stage. (e) The number and size of apoptotic bodies were inversely correlated with the progression of the cell cycle, with many small apoptotic bodies in early S phase and less but larger apoptotic bodies in late S phase (Nagy et al., 2004). Similar observations were made in K562 cells (Banfalvi et al., 2007). UV irradiation blocked chromatin condensation at its fibrillary stage, nuclear structures were blurred and covered with fibrillary chromatin, neither interphase nor metaphase chromosomes were visible." @default.
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- W1025016891 date "2008-01-01" @default.
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- W1025016891 title "Genotoxikus hatásra bekövetkező funkcionális és strukturális DNS változások = Functional and structural changes in DNA upon genotoxic effects" @default.
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