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- W102555241 abstract "In mammalian cells, the kynurenine pathway (KP) is a major biochemical route for the conversion of tryptophan, yielding L-kynurenine (L-KYN) and ultimately several other metabolites, called kynurenines, which derive directly or indirectly from L-KYN. Kynurenines have been shown to be involved in various physiological and pathological processes. Alteration of KP metabolism is functionally significant and occurs in a variety of diseases of the central nervous system. The discovery of the importance of kynurenines in brain function under physiological and pathologic conditions has led to the identification of potential new drug targets exploiting the therapeutic potential of the pathway. Some of these compounds proved to provide neuroprotection in animal models of various human diseases which holds promise that their effectiveness will translate to the clinic in the future. List of Abbreviations: EAA, excitatory amino acid; HD, Huntington’s disease; IDO, indoleamine 2,3‐ dioxygenase ; KAT II KO, kynurenine‐aminotransferase knockout; KP, The kynurenine pathway; KYNA, kynurenic acid; L‐KYN, L‐kynurenine; mNBA, meta‐nitrobenzoylalanine; MS, Multiple sclerosis; NAD, nicotinamide adenine dinucleotide; NMDA, N‐methyl‐D‐aspartate; oMBA, Ortho‐methoxybenzoylalanine; PD, Parkinson’s disease; QUIN, quinolinic acid; TDO, tryptophan dioxygenase; 3‐HAO, 3‐hydroxyanthranilate‐oxygenase; 3‐HK, 3‐hydroxykynurenine" @default.
- W102555241 created "2016-06-24" @default.
- W102555241 creator A5006824983 @default.
- W102555241 date "2009-01-01" @default.
- W102555241 modified "2023-09-27" @default.
- W102555241 title "5 Kynurenines in the Brain: Preclinical and Clinical Studies, Therapeutic Considerations" @default.
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