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• W1026429265 abstract "Because hearts with a temporally induced knockout of acyl-CoA synthetase 1 (Acsl1(T-/-)) are virtually unable to oxidize fatty acids, glucose use increases 8-fold to compensate. This metabolic switch activates mechanistic target of rapamycin complex 1 (mTORC1), which initiates growth by increasing protein and RNA synthesis and fatty acid metabolism, while decreasing autophagy. Compared with controls, Acsl1(T-/-) hearts contained 3 times more mitochondria with abnormal structure and displayed a 35-43% lower respiratory function. To study the effects of mTORC1 activation on mitochondrial structure and function, mTORC1 was inhibited by treating Acsl1(T-/-) and littermate control mice with rapamycin or vehicle alone for 2 wk. Rapamycin treatment normalized mitochondrial structure, number, and the maximal respiration rate in Acsl1(T-/-) hearts, but did not improve ADP-stimulated oxygen consumption, which was likely caused by the 33-51% lower ATP synthase activity present in both vehicle- and rapamycin-treated Acsl1(T-/-) hearts. The turnover of microtubule associated protein light chain 3b in Acsl1(T-/-) hearts was 88% lower than controls, indicating a diminished rate of autophagy. Rapamycin treatment increased autophagy to a rate that was 3.1-fold higher than in controls, allowing the formation of autophagolysosomes and the clearance of damaged mitochondria. Thus, long-chain acyl-CoA synthetase isoform 1 (ACSL1) deficiency in the heart activated mTORC1, thereby inhibiting autophagy and increasing the number of damaged mitochondria." @default.
• W1026429265 created "2016-06-24" @default.
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• W1026429265 date "2015-07-28" @default.
• W1026429265 modified "2023-10-17" @default.
• W1026429265 title "Loss of long‐chain acyl‐CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation" @default.
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• W1026429265 cites W1973416818 @default.
• W1026429265 cites W1973472942 @default.
• W1026429265 cites W1977810453 @default.
• W1026429265 cites W1980241433 @default.
• W1026429265 cites W1985802637 @default.
• W1026429265 cites W1987376048 @default.
• W1026429265 cites W1996745492 @default.
• W1026429265 cites W1997757665 @default.
• W1026429265 cites W2002194982 @default.
• W1026429265 cites W2004075497 @default.
• W1026429265 cites W2011253818 @default.
• W1026429265 cites W2012960310 @default.
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• W1026429265 cites W2018066433 @default.
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• W1026429265 cites W2030867177 @default.
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• W1026429265 cites W2040419103 @default.
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• W1026429265 cites W2063594418 @default.
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• W1026429265 cites W2157360228 @default.
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• W1026429265 doi "https://doi.org/10.1096/fj.15-272732" @default.
• W1026429265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4608904" @default.
• W1026429265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26220174" @default.
• W1026429265 hasPublicationYear "2015" @default.
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