FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W102699897> ?p ?o ?g. }

• W102699897 endingPage "76" @default.
• W102699897 startingPage "68" @default.
• W102699897 abstract "The complement system as a main column of innate immunity and the coagulation system as a main column in hemostasis undergo massive activation early after injury. Interactions between the two cascades have often been proposed but the precise molecular pathways of this interplay are still in the dark. To elucidate the mechanisms involved, the effects of various coagulation factors on complement activation and generation of anaphylatoxins were investigated and summarized in the light of the latest literature. Own in vitro findings suggest, that the coagulation factors FXa, FXIa and plasmin may cleave both C5 and C3, and robustly generate C5a and C3a (as detected by immunoblotting and ELISA). The produced anaphylatoxins were found to be biologically active as shown by a dose-dependent chemotactic response of neutrophils and HMC-1 cells, respectively. Thrombin did not only cleave C5 (Huber-Lang et al. 2006) but also in vitro-generated C3a when incubated with native C3. The plasmin-induced cleavage activity could be dose-dependently blocked by the serine protease inhibitor aprotinin and leupeptine. These findings suggest that various serine proteases belonging to the coagulation system are able to activate the complement cascade independently of the established pathways. Moreover, functional C5a and C3a are generated, both of which are known to be crucially involved in the inflammatory response." @default.
• W102699897 created "2016-06-24" @default.
• W102699897 creator A5013233663 @default.
• W102699897 creator A5023908387 @default.
• W102699897 creator A5024003678 @default.
• W102699897 creator A5048940037 @default.
• W102699897 creator A5067706625 @default.
• W102699897 creator A5073481189 @default.
• W102699897 creator A5074301183 @default.
• W102699897 creator A5085701512 @default.
• W102699897 date "2008-01-01" @default.
• W102699897 modified "2023-10-17" @default.
• W102699897 title "Interaction Between the Coagulation and Complement System" @default.
• W102699897 cites W1516140460 @default.
• W102699897 cites W1601018422 @default.
• W102699897 cites W1642037731 @default.
• W102699897 cites W1959181807 @default.
• W102699897 cites W1975107484 @default.
• W102699897 cites W1987074209 @default.
• W102699897 cites W2023108551 @default.
• W102699897 cites W2023205018 @default.
• W102699897 cites W2034522232 @default.
• W102699897 cites W2054169150 @default.
• W102699897 cites W2068551635 @default.
• W102699897 cites W2069078859 @default.
• W102699897 cites W2074687666 @default.
• W102699897 cites W2088926833 @default.
• W102699897 cites W2097802875 @default.
• W102699897 cites W2124551895 @default.
• W102699897 cites W2200944007 @default.
• W102699897 cites W2322121630 @default.
• W102699897 cites W2331901704 @default.
• W102699897 cites W2477936151 @default.
• W102699897 doi "https://doi.org/10.1007/978-0-387-78952-1_6" @default.
• W102699897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2713875" @default.
• W102699897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19025115" @default.
• W102699897 hasPublicationYear "2008" @default.
• W102699897 type Work @default.
• W102699897 sameAs 102699897 @default.
• W102699897 citedByCount "184" @default.
• W102699897 countsByYear W1026998972012 @default.
• W102699897 countsByYear W1026998972013 @default.
• W102699897 countsByYear W1026998972014 @default.
• W102699897 countsByYear W1026998972015 @default.
• W102699897 countsByYear W1026998972016 @default.
• W102699897 countsByYear W1026998972017 @default.
• W102699897 countsByYear W1026998972018 @default.
• W102699897 countsByYear W1026998972019 @default.
• W102699897 countsByYear W1026998972020 @default.
• W102699897 countsByYear W1026998972021 @default.
• W102699897 countsByYear W1026998972022 @default.
• W102699897 countsByYear W1026998972023 @default.
• W102699897 crossrefType "book-chapter" @default.
• W102699897 hasAuthorship W102699897A5013233663 @default.
• W102699897 hasAuthorship W102699897A5023908387 @default.
• W102699897 hasAuthorship W102699897A5024003678 @default.
• W102699897 hasAuthorship W102699897A5048940037 @default.
• W102699897 hasAuthorship W102699897A5067706625 @default.
• W102699897 hasAuthorship W102699897A5073481189 @default.
• W102699897 hasAuthorship W102699897A5074301183 @default.
• W102699897 hasAuthorship W102699897A5085701512 @default.
• W102699897 hasBestOaLocation W1026998972 @default.
• W102699897 hasConcept C111684460 @default.
• W102699897 hasConcept C118552586 @default.
• W102699897 hasConcept C141071460 @default.
• W102699897 hasConcept C170493617 @default.
• W102699897 hasConcept C181199279 @default.
• W102699897 hasConcept C182220744 @default.
• W102699897 hasConcept C185592680 @default.
• W102699897 hasConcept C19014433 @default.
• W102699897 hasConcept C202751555 @default.
• W102699897 hasConcept C203014093 @default.
• W102699897 hasConcept C2776414213 @default.
• W102699897 hasConcept C2776714187 @default.
• W102699897 hasConcept C2777292125 @default.
• W102699897 hasConcept C2777807008 @default.
• W102699897 hasConcept C2778382381 @default.
• W102699897 hasConcept C2780799893 @default.
• W102699897 hasConcept C2781071845 @default.
• W102699897 hasConcept C2910311954 @default.
• W102699897 hasConcept C52853521 @default.
• W102699897 hasConcept C54166955 @default.
• W102699897 hasConcept C55493867 @default.
• W102699897 hasConcept C71318922 @default.
• W102699897 hasConcept C71924100 @default.
• W102699897 hasConcept C86803240 @default.
• W102699897 hasConcept C8891405 @default.
• W102699897 hasConcept C89560881 @default.
• W102699897 hasConcept C90582226 @default.
• W102699897 hasConcept C95444343 @default.
• W102699897 hasConceptScore W102699897C111684460 @default.
• W102699897 hasConceptScore W102699897C118552586 @default.
• W102699897 hasConceptScore W102699897C141071460 @default.
• W102699897 hasConceptScore W102699897C170493617 @default.
• W102699897 hasConceptScore W102699897C181199279 @default.
• W102699897 hasConceptScore W102699897C182220744 @default.
• W102699897 hasConceptScore W102699897C185592680 @default.
• W102699897 hasConceptScore W102699897C19014433 @default.

• next