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- W1027125963 abstract "Publisher Summary This chapter highlights some of the functions of wingless protein (Wg) in cell fate determination. Wg has a role in patterning a variety of embryonic tissues; however, the best studied developmental role for Wg is in embryonic segmental patterning. Drosophila segmentation is regulated by both maternal and zygotic genes that pattern the embryo in a stepwise fashion. Initially, the anterior–posterior axis is established and then the embryo is subdivided into segmental units. This occurs in the syncytial blastoderm, a unique feature of Drosophila embryos, where the first 13 nuclear divisions occur in the absence of cellular divisions. After the cells have formed, the embryo begins to gastrulate, and patterning within each segmental unit begins. At this point, the embryonic epidermis is an epithelial monolayer that must establish and maintain polarity and specific cell fates within each segmental unit, as well as the borders between them. Prior to gastrulation, patterning of the blastoderm is directed by maternally and zygotically expressed genes, most of which encode transcription factors. However, once cellularization is complete and segments have been established, cell fate is determined by intercellular communication. The two signaling pathways that determine polarity and cell fate within each segmental unit are the Wg signaling pathway, the subject of this review, and the Hedgehog signaling pathway." @default.
- W1027125963 created "2016-06-24" @default.
- W1027125963 creator A5049978049 @default.
- W1027125963 date "1999-01-01" @default.
- W1027125963 modified "2023-09-25" @default.
- W1027125963 title "Role of Drosophila Wingless Signaling in Cell Fate Determination" @default.
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