FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1027356788> ?p ?o ?g. }

• W1027356788 endingPage "121" @default.
• W1027356788 startingPage "113" @default.
• W1027356788 abstract "Human head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type worldwide, possibly due to the significant role of alcohol and tobacco use in its development. Underlying most cancers are defects in mitochondrial functions such as energy metabolism and apoptosis. In fact, the mutations in mitochondrial DNA (mtDNA), which encode proteins for oxidative phosphorylation (OXPHOS), have been associated with human head and neck cancers. Here, we investigated the changes in the expression of OXPHOS complexes and the contribution of the defects in mitochondrial translation in the progression of HNSCC. Western blot analyses of the several stage IVA HNSCC primary tumors have shown reduction in the expression of COII and ATP5A of the OXPHOS complexes IV and V subunits, respectively. On the other hand, expression of the majority of the OXPHOS subunits, except complex II SDHB subunit, was impaired in a patient with a stage IV tumor with a regional lymph node. Interestingly, an overall reduction in one of the mitochondrial-encoded subunits of the complex IV, COII, accentuated a possible defect in mitochondrial translation machinery in two of the stage IVA tumors. Evidence provided in this study suggests for the first time that the mitochondrial translation defect(s) could be due to a decrease in the expression of one of the essential mitochondrial ribosomal proteins, MRPL11, in head and neck tumor biopsies. We also observed an acquired mitochondrial translation deficiency in the HN8 cell line derived from a lymph node metastasis but not in the HN22 cells derived from the primary tumor of the same patient. These seminal observations suggest that the mitochondrial translation machinery deserves further investigation for accurate molecular assessment and treatment of HNSCC." @default.
• W1027356788 created "2016-06-24" @default.
• W1027356788 creator A5000932395 @default.
• W1027356788 creator A5007302810 @default.
• W1027356788 creator A5011156190 @default.
• W1027356788 creator A5029972222 @default.
• W1027356788 creator A5038049613 @default.
• W1027356788 creator A5048834472 @default.
• W1027356788 creator A5085228927 @default.
• W1027356788 creator A5089922014 @default.
• W1027356788 date "2015-09-01" @default.
• W1027356788 modified "2023-10-15" @default.
• W1027356788 title "Impaired mitochondrial protein synthesis in head and neck squamous cell carcinoma" @default.
• W1027356788 cites W1970073870 @default.
• W1027356788 cites W1970748323 @default.
• W1027356788 cites W1975529948 @default.
• W1027356788 cites W1975874422 @default.
• W1027356788 cites W1976091683 @default.
• W1027356788 cites W1977199671 @default.
• W1027356788 cites W1979441281 @default.
• W1027356788 cites W1979484027 @default.
• W1027356788 cites W1981061928 @default.
• W1027356788 cites W1983989599 @default.
• W1027356788 cites W1989246472 @default.
• W1027356788 cites W1992071355 @default.
• W1027356788 cites W1995017064 @default.
• W1027356788 cites W2003152111 @default.
• W1027356788 cites W2006035995 @default.
• W1027356788 cites W2008523969 @default.
• W1027356788 cites W2015058580 @default.
• W1027356788 cites W2015364168 @default.
• W1027356788 cites W2021086569 @default.
• W1027356788 cites W2026488707 @default.
• W1027356788 cites W2027676112 @default.
• W1027356788 cites W2031567251 @default.
• W1027356788 cites W2032082852 @default.
• W1027356788 cites W2032835674 @default.
• W1027356788 cites W2033733148 @default.
• W1027356788 cites W2034773856 @default.
• W1027356788 cites W2037134079 @default.
• W1027356788 cites W2044710235 @default.
• W1027356788 cites W2057690410 @default.
• W1027356788 cites W2059969789 @default.
• W1027356788 cites W2061594903 @default.
• W1027356788 cites W2066005580 @default.
• W1027356788 cites W2069473693 @default.
• W1027356788 cites W2083157472 @default.
• W1027356788 cites W2084228837 @default.
• W1027356788 cites W2091677754 @default.
• W1027356788 cites W2101745552 @default.
• W1027356788 cites W2104903966 @default.
• W1027356788 cites W2116290593 @default.
• W1027356788 cites W2117692326 @default.
• W1027356788 cites W2120827026 @default.
• W1027356788 cites W2129526111 @default.
• W1027356788 cites W2140649827 @default.
• W1027356788 cites W2144627359 @default.
• W1027356788 cites W2159919133 @default.
• W1027356788 cites W2166544699 @default.
• W1027356788 cites W2170540646 @default.
• W1027356788 cites W2172052297 @default.
• W1027356788 doi "https://doi.org/10.1016/j.mito.2015.07.123" @default.
• W1027356788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26238294" @default.
• W1027356788 hasPublicationYear "2015" @default.
• W1027356788 type Work @default.
• W1027356788 sameAs 1027356788 @default.
• W1027356788 citedByCount "26" @default.
• W1027356788 countsByYear W10273567882016 @default.
• W1027356788 countsByYear W10273567882017 @default.
• W1027356788 countsByYear W10273567882018 @default.
• W1027356788 countsByYear W10273567882019 @default.
• W1027356788 countsByYear W10273567882020 @default.
• W1027356788 countsByYear W10273567882021 @default.
• W1027356788 countsByYear W10273567882022 @default.
• W1027356788 countsByYear W10273567882023 @default.
• W1027356788 crossrefType "journal-article" @default.
• W1027356788 hasAuthorship W1027356788A5000932395 @default.
• W1027356788 hasAuthorship W1027356788A5007302810 @default.
• W1027356788 hasAuthorship W1027356788A5011156190 @default.
• W1027356788 hasAuthorship W1027356788A5029972222 @default.
• W1027356788 hasAuthorship W1027356788A5038049613 @default.
• W1027356788 hasAuthorship W1027356788A5048834472 @default.
• W1027356788 hasAuthorship W1027356788A5085228927 @default.
• W1027356788 hasAuthorship W1027356788A5089922014 @default.
• W1027356788 hasConcept C104317684 @default.
• W1027356788 hasConcept C121608353 @default.
• W1027356788 hasConcept C142724271 @default.
• W1027356788 hasConcept C153911025 @default.
• W1027356788 hasConcept C24586158 @default.
• W1027356788 hasConcept C2776530083 @default.
• W1027356788 hasConcept C2776833033 @default.
• W1027356788 hasConcept C28859421 @default.
• W1027356788 hasConcept C502942594 @default.
• W1027356788 hasConcept C54355233 @default.
• W1027356788 hasConcept C55493867 @default.
• W1027356788 hasConcept C57600042 @default.
• W1027356788 hasConcept C71924100 @default.
• W1027356788 hasConcept C86803240 @default.

• next