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- W1027459310 abstract "Objectives We present a successful approach for desensitization for inhaled aztreonam (Cayston®), an effective treatment for patients with cystic fibrosis, infected with Pseudomonas aeruginosa, who have a type I hypersensitivity reaction to aztreonam. Background One patient developed diffuse rash and two patients developed pruritus, rash and hives after intravenous (IV) aztreonam. Intradermal skin testing to aztreonam performed by an allergist was positive for 0.001 mg/ML for two patients and not performed for the third. Methods All patients underwent inpatient desensitization. The protocol involved IV administration aztreonam arginine beginning at 0.002 mg and doubled after 15 minute intervals to a final dose of 1000 mg. After completion of the protocol, inhaled aztreonam was initiated at 75 mg every 8 hours immediately in two patients, and after three weeks of IV therapy in the third. Results Two patients successfully completed IV desensitization on the first attempt and transitioned to inhaled aztreonam at the next dosing interval. An extended 24 hour protocol was required for one patient who developed pruritus at step 12 of the original protocol (2 mg administered over one minute). After 5, 8, and 12 months of follow up, each described improved symptoms, less exacerbations, and improved quality of life. Conclusion Our first cohort of patients successfully desensitized to inhaled aztreonam. Although challenged with a strict time schedule and adherence to therapy, this may provide excellent long-term suppression of Pseudomonas aeruginosa without adverse systemic effects." @default.
- W1027459310 created "2016-06-24" @default.
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- W1027459310 date "2015-06-01" @default.
- W1027459310 modified "2023-09-29" @default.
- W1027459310 title "111 An overview of a desensitization protocol to inhaled aztreonam" @default.
- W1027459310 doi "https://doi.org/10.1016/s1569-1993(15)30288-5" @default.
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