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- W102791172 abstract "Publisher Summary Adequate renal perfusion pressure is essential to achieve diuretic-induced natriuresis. Hypotension and shock limit renal perfusion, but in many critically ill patients, renal perfusion pressure may not be reflected by the mean arterial pressure, owing to renal artery stenosis or vasoactive drug use. Adrenergic agonists, especially dopamine, have proven useful in increasing urinary salt and water excretion. In some situations, dopamine appears to have unique effects on the kidney. In patients with congestive heart failure, dopamine is clearly effective as a natriuretic and diuretic. Dopamine may also increase urine output in patients with acute renal function, but dopamine does not appear to accelerate recovery, or to be useful prophylactically. The chronic administration of oral dopamine agonists, especially ibopamine, to patients with impaired systolic function may improve cardiac hemodynamics and exercise tolerance, although not all results agree. Yet, it does not appear that these drugs are especially potent as natriuretic and diuretic agents on a chronic basis, as they appear to have little effect on cardiac preload. Effects of these drugs on mortality in this population have not been established, but they do not appear to cause the excess mortality that has been reported during administration of several oral inotropic agents. The role of these drugs in treating patients with congestive heart failure or hypertension remains to be established, but the development of oral dopamine agonists has helped to define the role of endogenous dopamine in cardiorenal function under normal and pathological conditions." @default.
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- W102791172 date "1997-01-01" @default.
- W102791172 modified "2023-09-25" @default.
- W102791172 title "Circulatory Support, Dopamine, and Dopamine Agonists as Adjuncts to Diuretic Therapy" @default.
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