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- W10279303 abstract "<Objectives> Intra-articular injection of hyaluronan (HA) is widely used in the treatment of knee osteoarthritis (OA). In the present study we established chronic arthritis in rabbit knee, applying the model of mice antigen-induced arthritis using methylated-BSA (m-BSA). Subsequently we investigated the effect of HA on this model. <Methods> Rabbits were immunized twice intradermally and elicited by intra-articular injection of m-BSA. Knee width (KW) and maximum extension angle (MEA) of knee were measured weekly as inflammatory and function indicators. HA (ARTZ ®, MW 840kDa) was injected once before and once a week for 5 weeks after elicitation. Six weeks later, animals were killed. Cell numbers, protein content and β-glucuronidase and N-acetyl-β-glucosaminidase in lavage fluid of the knee cavity, gross pathology and histology were assessed. <Results> Durable KW increases were seen in all elicited knees and MEA reductions were seen in over half of the rabbits. HA suppressed KW and synovium pathology significantly. Prevention of knee damage was also indicated by histology. Change of biological markers in knee lavage fluid and MEA of knee tended to be lower. <Conclusion> These results indicated that antigen-induced arthritis using m-BSA was useful as a chronic RA model. Intra-articular injection of HA into the disease knee was considered to be useful to prevent disease progression." @default.
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- W10279303 date "2002-01-01" @default.
- W10279303 modified "2023-09-26" @default.
- W10279303 title "EFFECTS OF HYALURONAN ON CHRONIC ARTHRITIS MODEL IN RABBIT" @default.
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- W10279303 doi "https://doi.org/10.1016/b978-1-85573-570-5.50284-0" @default.
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