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- W102795491 abstract "The discovery and development of molecularly targeted agents to treat cancer requires a new paradigm for moving novel drugs more rapidly through the development pipeline into the clinical setting. We must clearly understand the pharmacology (kinetics and dynamics) of each agent and the effect of the drug on its purported target(s). To optimize the development process, validated pharmacokinetic (PK) and pharmacodynamic (PD) assays must be available and used in the preclinical setting before advancing a new drug to clinical trials for first in-human studies. We present a new paradigm for moving through the discovery-developmental continuum that supports performing human pharmacologic studies earlier in drug development to shorten the time from target discovery to clinical evaluation." @default.
- W102795491 created "2016-06-24" @default.
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- W102795491 date "2007-12-25" @default.
- W102795491 modified "2023-09-30" @default.
- W102795491 title "Preclinical Development of Molecularly Targeted Agents in Oncology" @default.
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- W102795491 doi "https://doi.org/10.1007/978-1-59745-337-0_31" @default.
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