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- W102798407 abstract "Recently, the morbidity and mortality of breast cancer have markedly increased in Korea. Many studies were performed to find the genetic susceptibility genes that might be involved in oncogenesis and treatment of breast cancer in various ethnic populations. Among the susceptible genes, the BRCA1 and BRCA2 genes have been shown to be involved in hereditary breast cancer. To identify whether the polymorphisms in these genes are associated with breast cancer, genetic association study was performed for tag single nucleotide polymorphisms (SNPs) located in the BRCA1 and BRCA2 genes with 346 breast cancer patients and 361 healthy controls in Korean ethnic group. We could not find any significant associations between SNPs in BRCA1 and BRCA2 genes and breast cancer. A single linkage disequilibrium (LD) block from the BRCA1 gene, however, was significantly associated with breast cancer. The haplotype (ht1) of this LD block was increased the risk of breast cancer (OR=0.584, p=0.039) and haplotype (ht2) revealed a protective effect (OR=1.272, p=0.027). According to the premise of LD and previous reports, we hypothesized that any causative or protective variants contribute to or against breast cancer may exist in this LD block. In this presentation, possible causative variations in ht 1 and ht 2 will be discussed." @default.
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- W102798407 date "2008-03-01" @default.
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- W102798407 title "A linkage disequilibrium block from the BRCA1 gene was associated with breast cancer in Korean population" @default.
- W102798407 doi "https://doi.org/10.1096/fasebj.22.1_supplement.898.32" @default.
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