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- W1028972161 abstract "1390 Objectives: The importance of angiogenesis imaging is increasing in the diagnostic evaluation and treatment of cancer and other angiogenensis related disease. VEGFR-2 (KDR/Flk-1), are particularly attractive targets for molecular imaging because they are selectively overexpressed during tumor neovascularization. To obtain angiogenesis imaging, we prepared anti-VEGFR2 mAb conjugated chitosan (DC101-chitosan). Methods: Chitosan-SPDP was reacted with the thiol groups of DC101. DC101-chitosan was labeled with technetium and injected into B16F10 and HeLa tumor model via tail vein (300 uCi, 30 ug) followed by gamma camera imaging. I-125 DC101-chitosan was also injected into the melanoma model. Results: Chitosan-SPDP was successfully conjugated to DC101. This was confirmed by UV and Maldi-tof methods. Labeling efficiency was 95%. Image based tumor to opposite muscle ratio in melanoma model was 2.1, 3.1, 2.7 and in HeLa model was 1.3, 2.6, 3.3 at 5 min, 1 and 4 hr respectively. Biodistribution results of Tc-99m DC101-chitosan and I-125 DC101-chitosan in melanoma model were shown similar pattern except stomach and kidney. Conclusions: These results suggest that chitosan conjugates have potential for vascular imaging backbone in tumor xenografted animal model." @default.
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- W1028972161 date "2007-05-01" @default.
- W1028972161 modified "2023-09-27" @default.
- W1028972161 title "VEGF receptor 2 imaging in tumor model using Tc-99m DC101-chitosan" @default.
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