FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W102908478> ?p ?o ?g. }

• W102908478 endingPage "889" @default.
• W102908478 startingPage "880" @default.
• W102908478 abstract "A canine model of squamous cell lung cancer has been developed through studies with 110 dogs exposed by 11 focal endobronchial regimens to chemical carcinogens: benzo(a)pyrene, nitrosomethylurea, methylcholanthrene, and dimethylbenzanthracene. A combination of nitrosomethylurea and benzo(a)pyrene caused the first invasive cancer after 5.5 years. Toxic side-effects resulted from either nitrosomethylurea or high-dose dimethylbenzanthracene given by bronchial submucosal injection and from adjuvant immunosuppression with azathioprine and corticosteroids. Four regimens in 58 dogs caused 31 cancers, including five T1-2 N0 M0 cancers, 17 metastasizing carcinomas, and nine carcinomas of lesser stages. The following regimens caused cancers: sequential benzo(a)pyrene, nitrosomethylurea, and yttrium 91; benzo(a)pyrene and topical nitrosomethylurea; low-dose dimethylbenzanthracene; high-dose methylcholanthrene. The most suitable regimen to date has been 30 mg of methylcholanthrene given by submucosal injection every 2 to 3 weeks; this produced cancers at preselected sites within 2 years of first exposure in eight of 10 dogs. The neoplastic continuum has followed a predictable, reproducible sequence that regularly began with epithelial hyperplasia. Squamous metaplasia occurred in 6 to 18 weeks; it was followed by progressive squamous atypia. The interval until invasive cancer developed varied with the regimen employed; it was about 20 months with methylcholanthrene. Serial cytologic specimens, studied by image analysis, revealed progressive increase in mean total cellular deoxyribonucleic acid content from diploid in normal cells to greater than tetraploid in cancer cells (p less than 0.01). We have recently been successful with serial passage of four canine lung cancers from four to twelve transplant generations in nude mice. There is now a predictable large animal model of squamous cell lung carcinoma at preselected site(s) that closely resembles human lung cancer. The preneoplastic period is short enough to be fiscally defensible, but long enough to permit study of the biologic changes during endobronchial carcinogenesis." @default.
• W102908478 created "2016-06-24" @default.
• W102908478 creator A5008222499 @default.
• W102908478 creator A5023909763 @default.
• W102908478 creator A5029782037 @default.
• W102908478 creator A5043942295 @default.
• W102908478 creator A5056129587 @default.
• W102908478 creator A5089813671 @default.
• W102908478 date "1986-11-01" @default.
• W102908478 modified "2023-09-23" @default.
• W102908478 title "Endobronchial carcinogenesis in dogs" @default.
• W102908478 cites W2001524905 @default.
• W102908478 cites W2060834931 @default.
• W102908478 cites W2063909645 @default.
• W102908478 cites W2075792637 @default.
• W102908478 cites W2080558753 @default.
• W102908478 cites W2093610839 @default.
• W102908478 cites W2404072995 @default.
• W102908478 cites W2468376480 @default.
• W102908478 doi "https://doi.org/10.1016/s0022-5223(19)35848-9" @default.
• W102908478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3773544" @default.
• W102908478 hasPublicationYear "1986" @default.
• W102908478 type Work @default.
• W102908478 sameAs 102908478 @default.
• W102908478 citedByCount "11" @default.
• W102908478 crossrefType "journal-article" @default.
• W102908478 hasAuthorship W102908478A5008222499 @default.
• W102908478 hasAuthorship W102908478A5023909763 @default.
• W102908478 hasAuthorship W102908478A5029782037 @default.
• W102908478 hasAuthorship W102908478A5043942295 @default.
• W102908478 hasAuthorship W102908478A5056129587 @default.
• W102908478 hasAuthorship W102908478A5089813671 @default.
• W102908478 hasBestOaLocation W1029084781 @default.
• W102908478 hasConcept C114246631 @default.
• W102908478 hasConcept C121608353 @default.
• W102908478 hasConcept C126322002 @default.
• W102908478 hasConcept C142724271 @default.
• W102908478 hasConcept C2776256026 @default.
• W102908478 hasConcept C2781413609 @default.
• W102908478 hasConcept C54355233 @default.
• W102908478 hasConcept C71924100 @default.
• W102908478 hasConcept C86803240 @default.
• W102908478 hasConcept C90924648 @default.
• W102908478 hasConceptScore W102908478C114246631 @default.
• W102908478 hasConceptScore W102908478C121608353 @default.
• W102908478 hasConceptScore W102908478C126322002 @default.
• W102908478 hasConceptScore W102908478C142724271 @default.
• W102908478 hasConceptScore W102908478C2776256026 @default.
• W102908478 hasConceptScore W102908478C2781413609 @default.
• W102908478 hasConceptScore W102908478C54355233 @default.
• W102908478 hasConceptScore W102908478C71924100 @default.
• W102908478 hasConceptScore W102908478C86803240 @default.
• W102908478 hasConceptScore W102908478C90924648 @default.
• W102908478 hasIssue "5" @default.
• W102908478 hasLocation W1029084781 @default.
• W102908478 hasLocation W1029084782 @default.
• W102908478 hasOpenAccess W102908478 @default.
• W102908478 hasPrimaryLocation W1029084781 @default.
• W102908478 hasRelatedWork W1504979515 @default.
• W102908478 hasRelatedWork W1953835461 @default.
• W102908478 hasRelatedWork W1967103478 @default.
• W102908478 hasRelatedWork W2032912323 @default.
• W102908478 hasRelatedWork W2372561159 @default.
• W102908478 hasRelatedWork W2375344515 @default.
• W102908478 hasRelatedWork W2390152934 @default.
• W102908478 hasRelatedWork W4211039063 @default.
• W102908478 hasRelatedWork W4211182227 @default.
• W102908478 hasRelatedWork W4255387975 @default.
• W102908478 hasVolume "92" @default.
• W102908478 isParatext "false" @default.
• W102908478 isRetracted "false" @default.
• W102908478 magId "102908478" @default.
• W102908478 workType "article" @default.