FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1029387585> ?p ?o ?g. }

• W1029387585 endingPage "106" @default.
• W1029387585 startingPage "96" @default.
• W1029387585 abstract "Type 2 diabetes is a risk factor for Alzheimer's disease (AD). Previously, we have shown that the diabetes drug liraglutide is protective in middle aged and in old APP/PS1 mice. Here, we show that liraglutide has prophylactic properties. When injecting liraglutide once-daily ip. in two months old mice for 8 months, the main hallmarks of AD were much reduced. Memory formation in object recognition and Morris water maze were normalised and synapse loss and the loss of synaptic plasticity was prevented. In addition, amyloid plaque load, including dense core congophilic plaques, was much reduced. Chronic inflammation (activated microglia) was also reduced in the cortex, and neurogenesis was enhanced in the dentate gyrus. The results demonstrate that liraglutide may protect from progressive neurodegeneration that develops in AD. The drug is currently in clinical trials in patients with AD." @default.
• W1029387585 created "2016-06-24" @default.
• W1029387585 creator A5004424324 @default.
• W1029387585 creator A5043340675 @default.
• W1029387585 creator A5082707086 @default.
• W1029387585 date "2015-10-01" @default.
• W1029387585 modified "2023-10-18" @default.
• W1029387585 title "Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice" @default.
• W1029387585 cites W1539187429 @default.
• W1029387585 cites W1918909705 @default.
• W1029387585 cites W1966591940 @default.
• W1029387585 cites W1967256054 @default.
• W1029387585 cites W1967442749 @default.
• W1029387585 cites W1969181381 @default.
• W1029387585 cites W1970054581 @default.
• W1029387585 cites W1971310798 @default.
• W1029387585 cites W1972609075 @default.
• W1029387585 cites W1975141413 @default.
• W1029387585 cites W1982795519 @default.
• W1029387585 cites W1985305554 @default.
• W1029387585 cites W1990306590 @default.
• W1029387585 cites W1991562847 @default.
• W1029387585 cites W2009639401 @default.
• W1029387585 cites W2013775559 @default.
• W1029387585 cites W2015788437 @default.
• W1029387585 cites W2016932677 @default.
• W1029387585 cites W2022847635 @default.
• W1029387585 cites W2025558869 @default.
• W1029387585 cites W2026462831 @default.
• W1029387585 cites W2030270894 @default.
• W1029387585 cites W2043889992 @default.
• W1029387585 cites W2053725882 @default.
• W1029387585 cites W2058473463 @default.
• W1029387585 cites W2059348601 @default.
• W1029387585 cites W2060038665 @default.
• W1029387585 cites W2060170946 @default.
• W1029387585 cites W2065372294 @default.
• W1029387585 cites W2079158266 @default.
• W1029387585 cites W2079819090 @default.
• W1029387585 cites W2084071446 @default.
• W1029387585 cites W2085558085 @default.
• W1029387585 cites W2089665913 @default.
• W1029387585 cites W2118757715 @default.
• W1029387585 cites W2123319002 @default.
• W1029387585 cites W2127112728 @default.
• W1029387585 cites W2148456968 @default.
• W1029387585 cites W2148950507 @default.
• W1029387585 cites W2150472993 @default.
• W1029387585 cites W2154236525 @default.
• W1029387585 cites W2156788921 @default.
• W1029387585 cites W344771105 @default.
• W1029387585 doi "https://doi.org/10.1016/j.bbr.2015.07.024" @default.
• W1029387585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26205827" @default.
• W1029387585 hasPublicationYear "2015" @default.
• W1029387585 type Work @default.
• W1029387585 sameAs 1029387585 @default.
• W1029387585 citedByCount "82" @default.
• W1029387585 countsByYear W10293875852016 @default.
• W1029387585 countsByYear W10293875852017 @default.
• W1029387585 countsByYear W10293875852018 @default.
• W1029387585 countsByYear W10293875852019 @default.
• W1029387585 countsByYear W10293875852020 @default.
• W1029387585 countsByYear W10293875852021 @default.
• W1029387585 countsByYear W10293875852022 @default.
• W1029387585 countsByYear W10293875852023 @default.
• W1029387585 crossrefType "journal-article" @default.
• W1029387585 hasAuthorship W1029387585A5004424324 @default.
• W1029387585 hasAuthorship W1029387585A5043340675 @default.
• W1029387585 hasAuthorship W1029387585A5082707086 @default.
• W1029387585 hasBestOaLocation W10293875852 @default.
• W1029387585 hasConcept C126322002 @default.
• W1029387585 hasConcept C134018914 @default.
• W1029387585 hasConcept C15744967 @default.
• W1029387585 hasConcept C169760540 @default.
• W1029387585 hasConcept C2776464000 @default.
• W1029387585 hasConcept C2776914184 @default.
• W1029387585 hasConcept C2776925932 @default.
• W1029387585 hasConcept C2777180221 @default.
• W1029387585 hasConcept C2779134260 @default.
• W1029387585 hasConcept C2779830541 @default.
• W1029387585 hasConcept C2781161787 @default.
• W1029387585 hasConcept C2781308992 @default.
• W1029387585 hasConcept C44752575 @default.
• W1029387585 hasConcept C4746552 @default.
• W1029387585 hasConcept C502032728 @default.
• W1029387585 hasConcept C555293320 @default.
• W1029387585 hasConcept C71924100 @default.
• W1029387585 hasConceptScore W1029387585C126322002 @default.
• W1029387585 hasConceptScore W1029387585C134018914 @default.
• W1029387585 hasConceptScore W1029387585C15744967 @default.
• W1029387585 hasConceptScore W1029387585C169760540 @default.
• W1029387585 hasConceptScore W1029387585C2776464000 @default.
• W1029387585 hasConceptScore W1029387585C2776914184 @default.
• W1029387585 hasConceptScore W1029387585C2776925932 @default.
• W1029387585 hasConceptScore W1029387585C2777180221 @default.
• W1029387585 hasConceptScore W1029387585C2779134260 @default.
• W1029387585 hasConceptScore W1029387585C2779830541 @default.
• W1029387585 hasConceptScore W1029387585C2781161787 @default.

• next