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- W102965192 abstract "Since the observation by Labenz et al[1] that eradication of Helicobacter pylori (Hp) infection may be followed by development of reflux esophagitis in arelevant proportion of duodenal ulcer patients previously not affected by gastro esophageal reflux disease (GERD), a growing attention has been given to the potential interactions between Hp and GERD. Epidemiological studies have now demonstrated that the prevalence of GERD is steadily increasing in the developed countries[2], as is the incidence of adenocarcinoma of the esophagus[3], its most dangerous complication, while the prevalence of peptic ulcer and gastric cancer is falling[4], in parallel with a falling prevalence of Hp infection in the western countries[5]. It is therefore tempting to causally relate these phenomena. Despite the number of original paper s and of reviews dealing with this topic, at least 3 issues are still debated: ① Does Hp infection interfere with the pathogenesis of GERD ② Is the anti secretory effect of Hp infection of any clinical relevance in the management of GERD patients ③ Does long-term proton pump inhibitors (PPI) therapy accelerate development of atrophic changes in Hp + ve GERD patients. Finally, the relationship(s) between Hp and Barrett's esophagus may deserve some importance.The present review will focus on these 4 issues. The interested reader may also refer to some recent papers, dealing with the same subject[6-9]." @default.
- W102965192 created "2016-06-24" @default.
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- W102965192 date "2000-01-01" @default.
- W102965192 modified "2023-09-26" @default.
- W102965192 title "Gastroesophageal reflux and<i>Helicobacter pylori</i>: a review" @default.
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- W102965192 doi "https://doi.org/10.3748/wjg.v6.i3.311" @default.
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