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- W1029761367 abstract "We present data implicating mast cells within the myocardium in the development and progression of dilated cardiomyopathy (DCM). We show that the serine protease, mast cell tryptase, signals via the proteaseactivated receptor-2 (PAR-2). The receptor is expressed in abundance on fibroblasts and cardiomyocytes. We raised an antibody against the second extracellular loop of the PAR-2 receptor. This antibody had agonistic properties and acts in a fashion similar to the activating peptide SLIGKV. Our experiments implicate mast cells, mast cell tryptase, and PAR-2 receptor activation in DCM. They also shed light on possible autoimmune mechanisms contributing to DCM." @default.
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- W1029761367 date "2003-01-01" @default.
- W1029761367 modified "2023-10-18" @default.
- W1029761367 title "Effects of the Tryptase Receptor Activating Peptide and Antibodies Against the Tryptase Receptor Par-2 on Neonatal Rat Cardiomyocytes in Culture" @default.
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- W1029761367 doi "https://doi.org/10.1007/978-1-4419-9264-2_15" @default.
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