FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W103090994> ?p ?o ?g. }

• W103090994 abstract "Infection of total joint replacements is painful, disabling and difficult to treat because of the increasing bacterial resistance against antibiotics. In view of this, antiseptics show limited bacterial tolerance and have a broad-spectrum antimicrobial activity. However, the application of antiseptics to bone is insufficiently studied in literature. Therefore, we investigated the biocompatibility of the antiseptic polyhexanide with bone related cells and asked whether supplementation to bone cement is appropriate in the management of total arthroplasty infections.We performed an in vitro study with immortalised human foetal osteoblast cells (hFOB 1.19) and human endothelial cells (EAhy 926). The cultured cells were exposed to media containing various concentrations of gentamicin (12.5-800 microg/ml) and polyhexanide (0.0006-0.01%) for six hours. We measured the phase-contrast microscopy images, the cell viability, cell number and the alkaline phosphatase activity as a parameter for osteogenic function.The exposure of hFOB and endothelial cells to polyhexanide showed a severe reduction of viability and cell number. Gentamicin did not have negative effects on hFOB and endothelial cell number and viability. The alkaline phosphatase activity of hFOB showed a significant decrease after exposure to polyhexanide and gentamicin. The viability and the cell number of endothelial cells seem more negatively affected by polyhexanide than the parameters of the hFOB-cells.The exposure of human osteoblasts and endothelial cells to polyhexanide at concentrations with questionable antibacterial activity resulted in severe cell damage whereas exposure to high dosed gentamicin did not. These results raise questions as to the feasibility of using antiseptics in bone cement for the treatment of total arthroplasty infections. Further in vivo studies are necessary to show the in vivo relevance of these in vitro findings." @default.
• W103090994 created "2016-06-24" @default.
• W103090994 creator A5042866653 @default.
• W103090994 creator A5055177392 @default.
• W103090994 creator A5065449794 @default.
• W103090994 creator A5067120398 @default.
• W103090994 creator A5079690974 @default.
• W103090994 creator A5081657673 @default.
• W103090994 date "2007-03-10" @default.
• W103090994 modified "2023-09-25" @default.
• W103090994 title "Effect of polyhexanide and gentamycin on human osteoblasts and endothelial cells" @default.
• W103090994 cites W101279641 @default.
• W103090994 cites W1479795145 @default.
• W103090994 cites W1486154632 @default.
• W103090994 cites W1505091026 @default.
• W103090994 cites W1572581634 @default.
• W103090994 cites W1842787690 @default.
• W103090994 cites W1864582390 @default.
• W103090994 cites W2000780867 @default.
• W103090994 cites W2003612837 @default.
• W103090994 cites W2003891847 @default.
• W103090994 cites W2011311044 @default.
• W103090994 cites W2015475592 @default.
• W103090994 cites W2017454054 @default.
• W103090994 cites W2018364323 @default.
• W103090994 cites W2021280974 @default.
• W103090994 cites W2023350624 @default.
• W103090994 cites W2037548392 @default.
• W103090994 cites W2056228557 @default.
• W103090994 cites W2059765375 @default.
• W103090994 cites W2070089642 @default.
• W103090994 cites W2091648608 @default.
• W103090994 cites W2095593759 @default.
• W103090994 cites W2099374212 @default.
• W103090994 cites W2116316510 @default.
• W103090994 cites W2134201322 @default.
• W103090994 cites W2135513543 @default.
• W103090994 cites W2151844212 @default.
• W103090994 cites W2186652620 @default.
• W103090994 cites W2296689601 @default.
• W103090994 cites W2408771573 @default.
• W103090994 cites W2413146474 @default.
• W103090994 cites W2413451270 @default.
• W103090994 cites W57565900 @default.
• W103090994 cites W2124763838 @default.
• W103090994 doi "https://doi.org/10.4414/smw.2007.11434" @default.
• W103090994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17370154" @default.
• W103090994 hasPublicationYear "2007" @default.
• W103090994 type Work @default.
• W103090994 sameAs 103090994 @default.
• W103090994 citedByCount "9" @default.
• W103090994 countsByYear W1030909942012 @default.
• W103090994 countsByYear W1030909942016 @default.
• W103090994 countsByYear W1030909942018 @default.
• W103090994 countsByYear W1030909942021 @default.
• W103090994 crossrefType "journal-article" @default.
• W103090994 hasAuthorship W103090994A5042866653 @default.
• W103090994 hasAuthorship W103090994A5055177392 @default.
• W103090994 hasAuthorship W103090994A5065449794 @default.
• W103090994 hasAuthorship W103090994A5067120398 @default.
• W103090994 hasAuthorship W103090994A5079690974 @default.
• W103090994 hasAuthorship W103090994A5081657673 @default.
• W103090994 hasBestOaLocation W1030909941 @default.
• W103090994 hasConcept C160160445 @default.
• W103090994 hasConcept C181199279 @default.
• W103090994 hasConcept C185592680 @default.
• W103090994 hasConcept C202751555 @default.
• W103090994 hasConcept C203014093 @default.
• W103090994 hasConcept C2775832221 @default.
• W103090994 hasConcept C2778260815 @default.
• W103090994 hasConcept C501593827 @default.
• W103090994 hasConcept C53227056 @default.
• W103090994 hasConcept C55493867 @default.
• W103090994 hasConcept C71924100 @default.
• W103090994 hasConcept C86803240 @default.
• W103090994 hasConcept C89423630 @default.
• W103090994 hasConceptScore W103090994C160160445 @default.
• W103090994 hasConceptScore W103090994C181199279 @default.
• W103090994 hasConceptScore W103090994C185592680 @default.
• W103090994 hasConceptScore W103090994C202751555 @default.
• W103090994 hasConceptScore W103090994C203014093 @default.
• W103090994 hasConceptScore W103090994C2775832221 @default.
• W103090994 hasConceptScore W103090994C2778260815 @default.
• W103090994 hasConceptScore W103090994C501593827 @default.
• W103090994 hasConceptScore W103090994C53227056 @default.
• W103090994 hasConceptScore W103090994C55493867 @default.
• W103090994 hasConceptScore W103090994C71924100 @default.
• W103090994 hasConceptScore W103090994C86803240 @default.
• W103090994 hasConceptScore W103090994C89423630 @default.
• W103090994 hasLocation W1030909941 @default.
• W103090994 hasLocation W1030909942 @default.
• W103090994 hasLocation W1030909943 @default.
• W103090994 hasOpenAccess W103090994 @default.
• W103090994 hasPrimaryLocation W1030909941 @default.
• W103090994 hasRelatedWork W2013727734 @default.
• W103090994 hasRelatedWork W2014358708 @default.
• W103090994 hasRelatedWork W2022847144 @default.
• W103090994 hasRelatedWork W2347665948 @default.
• W103090994 hasRelatedWork W2370648588 @default.
• W103090994 hasRelatedWork W2384703214 @default.

• next