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- W10310909 abstract "Decidualization (D), the differentiation of stromal fibroblasts (SF) into decidual cells, is critical for pregnancy establishment. D requires the reorganization of the actin cytoskeleton that is governed by phosphorylation (P) of myosin light chain and actin dynamics. Manipulation of actin dynamics by jasplakinolide prevents D of human SF. Actin dynamics are regulated by actin-binding proteins, one of which is cofilin. The activity of cofilin depends on its P, which is regulated by LIMK1 and LIMK2. D of human SF is associated with changes in the distribution and activity of the proteins of the LIMK-cofilin pathway. D induced by a stimulus of embryonic origin, interleukin-1β (IL-1β) and steroid hormones (H), is accompanied by an upregulation of LIMK1, a downregulation of LIMK2 and the translocation of inactivated (phosphorylated) cofilin from the nucleus into the cytosol. On the other hand, D induced by an artificial stimulus cAMP (with H) is characterized by a significant decrease in phosphorylated cofilin and unchanged amounts of LIMK1 and LIMK2. Despite the differences in molecular mechanisms underlying the D induced by H alone, IL-1β+H or cAMP+H, the most striking observation during D is the translocation of cofilin from the cytosol to the nucleus. Taken together, the stabilization of F-actin significantly inhibits D; and the translocation of cofilin to the nucleus is a key feature of D. Supported by HD044713" @default.
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- W10310909 date "2008-03-01" @default.
- W10310909 modified "2023-10-14" @default.
- W10310909 title "Cofilin translocation to the nucleus is a key feature of decidualization" @default.
- W10310909 doi "https://doi.org/10.1096/fasebj.22.1_supplement.824.2" @default.
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