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- W103173735 abstract "Nine adult male Cynomolgus monkeys (Macaca fascicularis) were exposed for 10 min to 2.55 {plus minus} 0.03 ppm formaldehyde (HCHO; mean {plus minus} standard error of the mean, SEM) generated from formalin with a newly developed HCHO challenge system. The generation system was capable of producing highly stable HCHO vapor concentrations with fluctuations of HCHO concentrations of less than {plus minus} 5%. The experimental design included pre-exposure methacholine challenge to determine if responses to HCHO were associated with pre-existing bronchial hyperreactivity. Significant changes in average pulmonary flow resistance (R{sub L}) were observed (compared to control R{sub L} values) at 2, 5, and 10 min post-HCHO challenge. Pre-challenge R{sub L} values (mean {plus minus} SEM) were 11,3 {plus minus} 1,4 cm H{sub 2}O {center dot} l/s, while at 2, 5, and 10 min after HCHO challenge, values were 16,1 {plus minus} 2,1, 16,9 {plus minus} 2,8, and 20,0 {plus minus} 3,4 cm H{sub 2}O {center dot} l/s, respectively. Methacholine challenge data suggest that reactions to HCHO tend to be greater in monkeys hyperreactive to methacholine, but the relationship does not reach statistical significance in this small series of animals. These data indicate that significant pulmonary function deficits occur immediately after challengemore » with 2.55 ppm HCHO vapor in monkeys.« less" @default.
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- W103173735 date "1988-10-01" @default.
- W103173735 modified "2023-09-27" @default.
- W103173735 title "Acute airway narrowing in monkeys from challenge with 2. 5 ppm formaldehyde generated from formalin" @default.
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