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- W103181246 abstract "Mitochondria contribute to intracellular redox status and Ca2+ homeostasis. Intramitochondrial Ca2+ concentration are regulated via an electrophoretic uniporter that is driven by the transmembrane potential. Several abnormalities have been observed in the Ca2+ metabolism of spontaneously hypertensive rats (SHR). We studied whether mitochondrial membrane potential (mΔΨ), complex IV activity, and Ca2+ metabolism were altered in brain mitochondria of 1-month and 7-month SHR. We used safranine probe to determinate membrane potential. Complex IV activity was determinated measuring oxygen consumption with a Clark-type electrode. Ca2+ levels and uptake were determinated using Fluo-3AM and Arsenazo III. Ca2+ uptake was decreased in SHR compared to normotensive rats (WKY) of 1 month old. mΔΨ was lower in SHR than WKY 1-mo rats, while mΔΨ decreased in both 7-mo groups of rats. Complex IV activity decreased by 35% and 100% in 1-mo WKY and SHR rats, respectively, in the presence of 480 nmols Ca2+. Mitochondrial oxygen consumption decreased after addition of 480 nmols Ca2+ in 7-month SHR. mΔΨ decreased in the presence of 640 and 480 nmol Ca2+ in WKY and SHR, respectively. These data show an age-dependent decrease on complex IV activity of SHR activity parallel to a diminishing in mΔΨ, which impair [Ca2+]m and Ca2+-dependent mtNOS activity. Supported by Fondos Mixtos CONACYT-Gob. Edo. de Michoacán (64277, 64308), COECYT and CIC-UMSNH (2.16) grants." @default.
- W103181246 created "2016-06-24" @default.
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- W103181246 date "2008-03-01" @default.
- W103181246 modified "2023-09-26" @default.
- W103181246 title "Mitochondrial functionality and calcium uptake during hypertension in rat brain mitochondria" @default.
- W103181246 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1017.1" @default.
- W103181246 hasPublicationYear "2008" @default.
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