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- W103181510 abstract "The most striking molecular event during erythroid differentiation is the accumulation of haemoglobin but this is only one of many overt changes which occur in the maturing erythroid cell. Other proteins accumulate progressively, notably carbonic anhydrase and catalase while yet others, particularly the enzymes of haem synthesis, such as aminolaevulinic acid synthetase, accumulate during early maturation and diminish later (Freshney, R. I. and Paul, J. 1972). Membrane changes also occur. These include the accumulation of spectrin on the inner surface of the membrane, of specific antigens on the outer surface and changes in lectin binding properties. Simultaneously, there is progressive reduction of transcription leading eventually to a complete cessation of RNA synthesis and, indeed, in most mammals, to the extrusion of the nucleus itself. These changes are orchestrated in the orderly manner that we associate with many differentiating systems and, for this reason, erythropoiesis has been regarded as a very good model for investigating normal differentiation in mammals and, hopefully, therefore, for providing information about the mechanisms which are disturbed in leukaemia." @default.
- W103181510 created "2016-06-24" @default.
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- W103181510 date "1976-01-01" @default.
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- W103181510 title "Molecular Mechanisms in Erythroid Differentiation" @default.
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- W103181510 doi "https://doi.org/10.1007/978-3-642-87524-3_13" @default.
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